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Start Over Author "Mi Hyeon Cho" Journal journal of the american chemical society
2 results on '"Mi Hyeon Cho"'

1. Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles

Author

Thomas, Courtney R., Ferris, Daniel P., Jae-Hyun Lee, Eunjoo Choi, Mi Hyeon Cho, Eun Sook Kim, Stoddart, J. Fraser, Jeon-Soo Shin, Jinwoo Cheon, and Zink, Jeffrey I.

Subjects
Drug delivery systems -- Research, Semiconductor doping -- Analysis, Silica -- Chemical properties, Silica -- Electric properties, Zinc -- Chemical properties, Zinc -- Electric properties, Drugs -- Vehicles, Drugs -- Research, Chemistry
Abstract

A novel material that has incorporated zinc-doped iron oxide nanocrystals within a mesoporous silica framework that is surface-modified with pseudorotaxanes is described. This material is shown to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.

Published
2010

2. Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles

Author

Eun Sook Kim, Daniel P. Ferris, Mi Hyeon Cho, Jinwoo Cheon, Jeffrey I. Zink, Jae Hyun Lee, Eun Joo Choi, Courtney R. Thomas, J. Fraser Stoddart, and Jeon Soo Shin

Subjects
Surface Properties, Nanoparticle, Antineoplastic Agents, Nanotechnology, Biochemistry, Catalysis, Nanomaterials, Magnetics, Drug Delivery Systems, Colloid and Surface Chemistry, Cell Line, Tumor, Humans, Particle Size, Cell Death, Chemistry, General Chemistry, Mesoporous silica, Silicon Dioxide, Controlled release, Molecular machine, Nanocrystal, Doxorubicin, Drug delivery, Nanoparticles, Particle size, Porosity
Abstract

Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.

Published
2010

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