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Start Over Author "KANG Hua" Journal journal of the american chemical society
6 results on '"KANG Hua"'

1. Electrochemical Detection of a Few Copies of Unamplified SARS-CoV-2 Nucleic Acids by a Self-Actuated Molecular System

Author

Ji, Daizong, primary, Guo, Mingquan, additional, Wu, Yungen, additional, Liu, Wentao, additional, Luo, Shi, additional, Wang, Xuejun, additional, Kang, Hua, additional, Chen, Yiheng, additional, Dai, Changhao, additional, Kong, Derong, additional, Ma, Hongwenjie, additional, Liu, Yunqi, additional, and Wei, Dacheng, additional

Published
2022
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4. Rhodium/Silver Synergistic Catalysis in Highly Enantioselective Cycloisomerization/Cross Coupling of Keto-Vinylidenecyclopropanes with Terminal Alkynes

Author

Qin Xu, Song Yang, Xiang-Ying Tang, Min Shi, and Kang-Hua Rui

Subjects
010405 organic chemistry, Enantioselective synthesis, chemistry.chemical_element, Regioselectivity, General Chemistry, 010402 general chemistry, Cleavage (embryo), 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Rhodium, Transmetalation, Colloid and Surface Chemistry, Cycloisomerization, chemistry, Organic chemistry, Synergistic catalysis
Abstract

A rhodium/silver synergistic catalysis has been established, enabling cycloisomerization/cross coupling of keto-vinylidenecyclopropanes (VDCPs) with terminal alkynes toward the regio- and enantioselective formation of diversified tetrahydropyridin-3-ol tethered 1,4-enynes in good yields and high ee values. In this synergistic catalysis, Rh(I) and Ag(I) catalysts selectively activate keto-VDCP substrates and terminal alkynes to generate the π-allyl Rh(III) complex of oxa-rhodacyclic intermediate and Ag alkynyl intermediate, respectively. The rapid transmetalation of alkynyl groups from Ag to Rh is proposed to play a key role in realizing the regioselective cleavage of the distal bond of the three-membered ring in this transformation.

Published
2017

6. Rhodium/Silver Synergistic Catalysis in Highly Enantioselective Cycloisomerization/Cross Coupling of Keto-Vinylidenecyclopropanes with Terminal Alkynes.

Author

Song Yang, Kang-Hua Rui, Xiang-Ying Tang, Qin Xu, and Min Shi

Subjects
*RHODIUM, *ELECTROMETALLURGY of silver, *CYCLOISOMERIZATION, *ALKYNES, *ENANTIOSELECTIVE catalysis
Abstract

A rhodium/silver synergistic catalysis has been established, enabling cycloisomerization/cross coupling of keto-vinylidenecyclopropanes (VDCPs) with terminal alkynes toward the regio- and enantioselective formation of diversified tetrahydropyridin-3-ol tethered 1,4-enynes in good yields and high ee values. In this synergistic catalysis, Rh(I) and Ag(I) catalysts selectively activate keto-VDCP substrates and terminal alkynes to generate the π-allyl Rh(III) complex of oxa-rhodacyclic intermediate and Ag alkynyl intermediate, respectively. The rapid transmetalation of alkynyl groups from Ag to Rh is proposed to play a key role in realizing the regioselective cleavage of the distal bond of the three-membered ring in this transformation. [ABSTRACT FROM AUTHOR]

Published
2017
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