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Fourteen novel ferrocene derivatives have been designed to serve as receptors for low molecular weight diamines. The compounds that have been prepared and fully characterized possess two ferrocenedicarboxylic acid residues bridged by amide formation in their respective 1‘-positions by 4,4‘-benzidinyl (15), 3,3‘-dimethoxy-4,4‘-benzidinyl (16), 2,7-fluorenyl (17), 3-methoxy-2,7-fluorenyl (18), 4-N-piperazinoanilinyl (19), N,N‘-4,4‘-bipiperdinyl (20), and 4,13-diaza-18-crown-6 (21). In two cases, ferrocenecarboxylic acid was bridged by spacers attached using 1-methylene groups. The bridges in these cases were 4,13-diaza-18-crown-6 (22) and 1,5-diaminoanthraquinone (24). In a single case, ferrocenecarboxylic acid was bridged by 1,5-dicarbonylnaphthalene (25). In one additional case, the bridge was created by formation of an imine followed by hydrogenation, but both compounds (26, 27) proved to be relatively unstable. Attempts to increase solubility afforded the N-ethylated derivative 28 of 15 and the derivati...

The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps.

Three novel ferrocene-crown derivatives have been prepared along with their previously known amide precursors. The new compounds include 1,1'-(1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-dimethyl)ferrocene (2), N,N'-bis(ferrocenylmethyl)diaza-18-crown-6 (4), mp 114-116 o C, and bis[N,N'-bis(cyclopentadienidylmethyl)-4,13-diaza-18-crown-6]diiron (6), mp 104-106 o C. Solid-state structures have been obtained for 2.H 2 O (mp 101-104 ) C) and for Na + ClO 4 - (mp 208-215 ) C dec and Ag + ClO 4 - (mp 209-210 ° C dec) complexes of 2

We report here a novel class of ferrocenyl steroids and present the first evidence for aggregation of these systems and particularly for vesicle formation controlled by redox-switched ferrocene amphiphiles

Utilisation de la levure Saccharomyces cerevisiae pour la synthese asymetrique de sterol a partir de squalene