1. Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo
- Author
-
Hui Li, Juan Chen, Jerry D. Glickson, Ian R. Corbin, Weiguo Cao, and Gang Zheng
- Subjects
Nanoparticle ,Conjugated system ,Ligands ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Mice ,Colloid and Surface Chemistry ,In vivo ,Cell Line, Tumor ,Cricetinae ,Animals ,Humans ,Receptor ,Microscopy, Confocal ,General Chemistry ,Neoplasms, Experimental ,Lipoproteins, LDL ,chemistry ,Low-density lipoprotein ,LDL receptor ,Biophysics ,Nanoparticles ,lipids (amino acids, peptides, and proteins) ,Nanocarriers ,Drug carrier - Abstract
LDL particles are high-capacity nanocarriers with precisely controlled size and are naturally biocompatible, biodegradable, and nonimmunogenic. However, their utilities as drug carriers are limited by the narrow purview of LDL receptor-positive tumors. Here, we synthsized a ligand-conjugated, NIR-labeled LDL that enables the first in vivo demonstration of rerouting LDL from LDL receptors to selected alternate receptors, thus drastically expanding the range of using LDL particles as nanocarriers for in vivo cancer imaging and treatment.
- Published
- 2007