1. Supramolecular 'Trojan Horse' for Nuclear Delivery of Dual Anticancer Drugs
- Author
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Jie Gao, Yanbin Cai, Haosheng Shen, Liuhan Dai, Chunhua Ren, Yang Shi, Mingliang Lin, Jie Zhan, Zhimou Yang, and Jianfeng Liu
- Subjects
Macromolecular Substances ,Cell ,Antineoplastic Agents ,02 engineering and technology ,Pharmacology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,Mice ,Colloid and Surface Chemistry ,Drug Delivery Systems ,In vivo ,Cell Line, Tumor ,Neoplasms ,Amphiphile ,medicine ,Animals ,Humans ,Cell Proliferation ,Cisplatin ,Drug Carriers ,Molecular Structure ,Chemistry ,Trojan horse ,Combination chemotherapy ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,medicine.anatomical_structure ,Nanomedicine ,Cancer cell ,Cancer research ,Camptothecin ,Drug Screening Assays, Antitumor ,0210 nano-technology ,medicine.drug - Abstract
Nuclear delivery and accumulation are very important for many anticancer drugs that interact with DNA or its associated enzymes in the nucleus. However, it is very difficult for neutrally and negatively charged anticancer drugs such as 10-hydroxycamptothecine (HCPT). Here we report a simple strategy to construct supramolecular nanomedicines for nuclear delivery of dual synergistic anticancer drugs. Our strategy utilizes the coassembly of a negatively charged HCPT-peptide amphiphile and the positively charged cisplatin. The resulting nanomaterials behave as the “Trojan Horse” that transported soldiers (anticancer drugs) across the walls of the castle (cell and nucleus membranes). Therefore, they show improved inhibition capacity to cancer cells including the drug resistant cancer cell and promote the synergistic tumor suppression property in vivo. We envision that our strategy of constructing nanomaterials by metal chelation would offer new opportunities to develop nanomedicines for combination chemotherapy.
- Published
- 2017