1. Enantiopure Peptide-Functionalized Metal-Organic Frameworks.
- Author
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Bonnefoy, Jonathan, Legrand, Alexandre, Quadrelli, Elsje Alessandra, Canivet, Jérôme, and Farrusseng, David
- Subjects
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METAL-organic frameworks , *OLIGOPEPTIDES , *AMINO acids , *CHEMICAL yield , *MOLECULAR recognition , *CATALYSIS - Abstract
We present herein the first example of metal-organic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH2, In-MIL-68-NH2, and Zr-UiO-66-NH2 were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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