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Start Over Author "J. Butterfield" Journal journal of the american academy of dermatology
9 results on '"J. Butterfield"'

2. Comorbidities and diabetic complications in patients with necrobiosis lipoidica

Author

Meera H. Patel, Caitlin M. Brumfiel, Ilana Breen, Kevin J. Severson, A. Sekulic, Richard J. Butterfield, Aaron R. Mangold, Mark R. Pittelkow, and Steven A. Nelson

Subjects
medicine.medical_specialty, Necrobiosis Lipoidica, business.industry, Comorbidity, Dermatology, medicine.disease, Necrobiosis lipoidica, Diabetes Complications, Diabetes Mellitus, Type 1, Diabetes mellitus, medicine, Humans, In patient, business
Published
2022
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3. Clinical and morphological features of necrobiosis lipoidica

Author

Caitlin M. Brumfiel, Meera H. Patel, Kevin J. Severson, Steven A. Nelson, Richard J. Butterfield, Collin M. Costello, Aaron R. Mangold, and Mark R. Pittelkow

Subjects
medicine.medical_specialty, Necrobiosis Lipoidica, Demographics, business.industry, MEDLINE, Dermatology, medicine.disease, Necrobiosis lipoidica, Diabetes Mellitus, Type 1, Diabetes mellitus, medicine, Humans, business
Published
2022
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4. Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: Diagnosis and management

Author

Allison C. Rosenthal, Fiona E. Craig, Kevin J. Severson, Jason C. Sluzevich, Jordan M. Montoya, Jake Besch-Stokes, William G. Rule, David J. DiCaudo, Aaron R. Mangold, Mark R. Pittelkow, Puneet Bhullar, Nneka I. Comfere, Collin M. Costello, and Richard J. Butterfield

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Primary (chemistry), Text mining, business.industry, T cell, medicine, MEDLINE, Dermatology, business
Published
2022
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5. Necrobiosis lipoidica-associated cutaneous malignancy

Author

Caitlin M. Brumfiel, Jamison A. Harvey, Mark R. Pittelkow, Kevin J. Severson, Richard J. Butterfield, Steven A. Nelson, Aaron R. Mangold, Aleksandar Sekulic, and Meera H. Patel

Subjects
medicine.medical_specialty, Cutaneous squamous cell carcinoma, Skin Neoplasms, Necrobiosis Lipoidica, business.industry, Melanoma, Dermatology, medicine.disease, Malignancy, Necrobiosis lipoidica, Diabetes mellitus, medicine, Humans, Basal cell carcinoma, business, Cutaneous malignancy
Published
2021

6. Primary cutaneous CD4

Author

Jake G, Besch-Stokes, Collin M, Costello, Kevin J, Severson, Puneet, Bhullar, Jordan, Montoya, Richard J, Butterfield, David J, DiCaudo, Nneka, Comfere, Jason, Sluzevich, William, Rule, Fiona E, Craig, Allison, Rosenthal, Mark R, Pittelkow, and Aaron R, Mangold

Subjects
CD4-Positive T-Lymphocytes, Skin Neoplasms, Humans, Lymphoproliferative Disorders, Lymphoma, T-Cell, Cutaneous, Skin
Published
2020

8. 26941 The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma in a random sampling representative of the general population

Author

A. Sekulic, Nan Zhang, Richard J. Butterfield, Caitlin M. Brumfiel, Steven A. Nelson, Mark R. Pittelkow, Meera H. Patel, David J. DiCaudo, Aaron R. Mangold, and Kevin J. Severson

Subjects
education.field_of_study, Cutaneous squamous cell carcinoma, business.industry, Polyphosphate, Population, Phosphatase, Dermatology, chemistry.chemical_compound, chemistry, Cancer research, Medicine, Inositol, education, business, Value (mathematics)
Published
2021
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9. The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma

Author

David J. DiCaudo, Aaron R. Mangold, Helen J.L. Cumsky, Collin M. Costello, Jessica Schmidt, Kevin Drenner, Christian L. Baum, Nan Zhang, Mark R. Pittelkow, Richard J. Butterfield, Aleksandar Sekulic, Shari A. Ochoa, Steven A. Nelson, and Matthew R. Buras

Subjects
Oncology, Male, medicine.medical_specialty, Skin Neoplasms, Phosphatase, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, Medicine, Humans, Inositol, Neoplasm Invasiveness, Peripheral Nerves, Stage (cooking), Neoplasm Metastasis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Hazard ratio, Actinic keratosis, Inositol Polyphosphate 5-Phosphatases, Middle Aged, medicine.disease, Prognosis, Tumor Burden, Keratosis, Actinic, Survival Rate, chemistry, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Biomarker (medicine), Immunohistochemistry, Histopathology, Female, Neoplasm Grading, business
Abstract

Inositol polyphosphate 5-phosphatase (INPP5A) has been shown to play a role in development and progression of cutaneous squamous cell carcinoma (cSCC). The goal of the current study was to explore the prognostic value of INPP5A expression in cSCC.A total of 189 cases of actinic keratosis and SCC in 174 patients were identified; clinical and outcome data were abstracted, histopathology was rereviewed, and immunohistochemical staining and interpretation was performed for INPP5A.The majority of tumors (89.4%) had an INPP5A score of 2 or 3. No patients had complete loss of INPP5A. Tumors with an INPP5A score of 1 were more likely to be intermediate- to high-risk tumors (Brigham and Women's Hospital stage ≥T2a 85.0% vs 23.7% [P .0001]) characterized by a larger diameter (2.4 cm vs 1.3 cm [P = .0004]), moderate-to-poor differentiation (86.7% vs 17.6% [P .0001]), and perineural invasion (37.5% vs 5.3%, [P .0001]). An INPP5A score of 1 was associated with a worse 3-year survival (a rate of 42.3% [hazard ratio, 2.81, P = .0006]) and a local metastasis rate of 48.0% (hazard ratio, 4.71; P .0001).Low INPP5A scores are predictive of aggressive tumors and may be a useful adjunct to guide clinical management of cSCC.

Published
2018

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