1. Registry‐based randomized clinical trials in surgery: Working with ACS‐NSQIP and the AHPBA to conduct pragmatic trials
- Author
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Ecker, Brett L, Brajcich, Brian C, Ellis, Ryan J, Ko, Clifford Y, and D'Angelica, Michael I
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Comparative Effectiveness Research ,Clinical Trials and Supportive Activities ,Clinical Research ,Patient Safety ,8.4 Research design and methodologies (health services) ,Health and social care services research ,Humans ,Neoplasms ,Quality of Health Care ,Randomized Controlled Trials as Topic ,Registries ,Surgical Oncology ,pragmatic clinical trial ,randomized controlled trials ,registry-based trials ,surgical registry ,surgical research methods ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Randomized controlled trials (RCTs) represent the gold standard for evidence in clinical medicine because of their ability to account for the effects of unmeasured confounders and selection bias by indication. However, their complexity and immense costs limit their application, and thus the availability of high-quality data to guide clinical care. Registry-based RCTs are a type of pragmatic trial that leverages existing registries as a platform for data collection, providing a low-cost alternative for randomized studies. Herein, we describe the tenets of registry RCTs and the development of the first AHPBA/ACS-NSQIP-based registry trial.
- Published
- 2022