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A novel complex [CoII(L)2·CH3OH] with hydrazone derived from protocatechuic acid (HL=C16H14N2O4) is designed and synthesized. The complex is characterized by single crystal X-ray diffraction, elemental analysis, IR, and thermal gravimetric analysis. The complex crystallizes in the monoclinic space group C2/c, with unit cell dimensions a = 25.1715(11), b = 9.3518(4), c = 12.8700(6) Å, β = 103.6530(10)°, V = 2943.98(75) Å3, Z = 4, R1 = 0.0612, and wR2 = 0.1439. [ABSTRACT FROM AUTHOR]

A new caffeic acid derivative (( E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid, HL)) is synthesized from caffeic acid, followed by the preparation of a Cu(II) complex, [Cu(L)DMSO]·2DMSO. The structure is determined by single crystal X-ray diffraction, and the urease inhibitory activity of the complex is studied. The results show that IC of the complex is 0.56 μmol/L, which is superior to positive control acetohydroxamic acid (AHA, IC was 10.95 μmol/l), i.e., the complex has strong inhibitory activity towards urease. [ABSTRACT FROM AUTHOR]