1. The hormonal and cellular control of Sertoli cell secretion
- Author
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J P, Mather, G L, Gunsalus, N A, Musto, C Y, Cheng, M, Parvinen, W, Wright, V, Pérez-Infante, A, Margioris, A, Liotta, R, Becker, D T, Krieger, and C W, Bardin
- Subjects
Epididymis ,Male ,Sertoli Cells ,Leydig Cells ,Proteins ,Seminiferous Tubules ,Androgen-Binding Protein ,Rats ,Mice ,Testis ,Animals ,Insulin ,Follicle Stimulating Hormone ,Carrier Proteins - Abstract
Sertoli cells synthesize and secrete a number of cell-specific products including androgen binding protein (ABP), as well as "serum proteins" such as transferrin. The secretion of these proteins is regulated by extra-testicular hormones such as FSH and insulin; Leydig cell-produced steroids and proopiomelano-cortin-derived peptides; and the presence of peritubular myoid cells and/or factors secreted by these cells. Many of the Sertoli cell proteins are secreted in a cyclic fashion during the different stages of the spermatogenic cycle suggesting communication between Sertoli cells and developing germ cells. The availability of quantitative measurements for Sertoli cell-specific proteins such as ABP make it feasible to follow Sertoli cell function in vivo by measuring these products in serum. A bidirectional secretion of proteins by Sertoli cells is proposed to explain the presence of specific peptides in the male reproductive tract and blood.
- Published
- 1983