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This paper explores the sedimentary provenance of the Silurian to Devonian siliciclastic successions in the Central region of the San Juan Precordillera, in central-western Argentina. The comprehensive provenance analysis of the Tambolar Formation (upper Silurian), Talacasto Formation (Lower Devonian) and Punta Negra Formation (Lower-Middle Devonian) from the San Juan River section is based on petrography, detrital zircon analyses and combined U–Pb and Lu–Hf isotopic data. Modal composition of the three units here studied shows an evolution trend from quartzose recycled, mixed, to transitional arc. Detrital zircon morphologies indicate derivation from dominantly plutonic and metamorphic sources with little evidence of transportation. The most representative detrital zircon U–Pb age populations are Famatinian (middle Cambrian - Devonian), Pampean–Brazilian (Tonian - lower Cambrian), and Grenvillian (Ectasian - Stenian) cycles derived rocks. Hf isotopes determined mainly in Mesoproterozoic detrital zircons reflect a juvenile mantle source during crystallization, with less significant inputs from those with a crustal and recycled crust origin. Results from this work are compared to data from outcrops of the same units developed in the North-Central region of the Precordillera, presented in previous works. Provenance proxies provide insights regarding the correlation of probably equivalent units deposited in other foreland basins within the Cuyania terrane, such as the Villavicencio Formation (Mendoza Precordillera), Río Seco de los Castaños and La Horqueta Formations (San Rafael Block). The K–S test suggests a low correlation between the units studied at the San Juan River and the equivalent outcrops exposed towards the central and northern parts of the San Juan Precordillera, as well as with the known records of the Río Seco de los Castaños and La Horqueta Formations of the San Rafael Block. In contrast, the samples from the Villavicencio Formation show a high correlation with the sample from the Punta Negra Formation, indicating a possible common sediment source. The broad variations of U–Pb detrital age pattern distributions observed between Silurian and Devonian successions throughout the Precordillera and the San Rafael Block point to provenance shifts linked to variability in east-to-west sediment dispersal patterns within an axial peripheral foreland basin. Fluctuations in the sedimentary composition are ascribed to the differential exhumation rate of source rocks and a progression from a convergent tectonic setting in the San Rafael block towards a coeval collisional environment in the Precordillera. The Silurian - Early Devonian foreland basin is tectonically linked to the Ocloyic Orogen that resulted from the collision of Cuyania terrane to the Western margin of Gondwana. Source rocks were most likely located within the Mesoproterozoic basement of Cuyania, exhumed during the Middle Devonian as a response to the approximation of Chilenia. • A Provenance analysis, of the Silurian to Devonian Precordillera successions of the San Juan River section is here presented. • The approach of Chilenia to the west of Gondwana exhumed the basement rocks of the previously accreted Cuyania terrane, allowing erosion and sedimentation of their debris during Middle Devonian times. • Hf isotopes in Mesoproterozoic detrital zircons reflect a juvenile mantle source during crystallization. • Provenance proxies here presented indicate a lack of connection between depocenters of the Precordillera and the San Rafael Block. [ABSTRACT FROM AUTHOR]