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Your search keyword '"Siegel, Jerome M"' showing total 7 results
Start Over Author "Siegel, Jerome M" Journal journal of sleep research
7 results on '"Siegel, Jerome M"'

1. Striking cessation of cataplexy by opioids

Author

Donjacour, Claire EHM, Lammers, Gert Jan, and Siegel, Jerome M

Subjects
Biomedical and Clinical Sciences, Psychology, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences
Published
2019

2. Obstructive sleep apnea is associated with low GABA and high glutamate in the insular cortex.

Author

Macey, Paul M, Sarma, Manoj K, Nagarajan, Rajakumar, Aysola, Ravi, Siegel, Jerome M, Harper, Ronald M, and Thomas, M Albert

Subjects
Cerebral Cortex, Autonomic Nervous System, Humans, Sleep Apnea, Obstructive, gamma-Aminobutyric Acid, Glutamic Acid, Magnetic Resonance Imaging, Case-Control Studies, Middle Aged, Female, Male, Neuroimaging, autonomic, intermittent excitoxicity hypoxia, neurotransmitter, Neurosciences, Clinical Research, Lung, Sleep Research, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The insular cortex is injured in obstructive sleep apnea (OSA) and responds inappropriately to autonomic challenges, suggesting neural reorganization. The objective of this study was to assess whether the neural changes might result from γ-aminobutyric acid (GABA) and glutamate alterations. We studied 14 OSA patients [mean age ± standard deviation (SD): 47.5 ± 10.5 years; nine male; apnea-hypopnea index (AHI): 29.5 ± 15.6 events h(-1) ] and 22 healthy participants (47.5 ± 10.1 years; 11 male), using magnetic resonance spectroscopy to detect GABA and glutamate levels in insular cortices. We localized the cortices with anatomical scans, and measured neurochemical levels from anterior to mid-regions. Left and right anterior insular cortices showed lower GABA and higher glutamate in OSA versus healthy subjects [GABA left: OSA n = 6: 0.36 ± 0.10 (mean ± SD), healthy n = 5: 0.62 ± 0.18; P

Published
2016

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