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Your search keyword '"Ming Mu"' showing total 4 results
Start Over Author "Ming Mu" Journal journal of separation science
4 results on '"Ming Mu"'

1. Ultrasound and surfactant‐assisted dispersive liquid–liquid microextraction prior to poly(ethylene oxide)‐mediated stacking in CE for highly sensitive determination of barbiturates in human fluids.

Author

Tseng, Li Hsin, Liang, Pei‐Chi, Chiu, Tai‐Chia, and Hsieh, Ming‐Mu

Subjects
BARBITURATES, CHEMICAL preconcentration, CAPILLARY electrophoresis, ULTRASONIC imaging, SODIUM phosphates, FLUIDS, ETHYLENE oxide
Abstract

This study developed a facile, highly sensitive technique for extracting and quantifying barbiturates in serum samples. This method combined ultrasound and surfactant‐assisted dispersive liquid–liquid microextraction with poly(ethylene oxide)‐mediated stacking in capillary electrophoresis. Factors influencing the extraction and stacking performance, such as the type and volume of extraction solvents, the type and concentration of surfactant, extraction time, salt additives, sample matrix, solution pH, and composition of the background electrolyte, were carefully studied and optimized to achieve the optimal detection sensitivity. Under the optimized extraction (injecting 140 μL C2H4Cl2 into 1 mL of sample with pH 4 (5 mM sodium phosphate containing 0.05 mM Tween 20 and sonication for 1 min) and separation conditions (150 mM tris(hydroxymethyl)aminomethane‐borate with pH 8.5 containing 0.5% (m/v) poly(ethylene oxide)), the limits of detection (signal‐to‐noise ratio = 3) of five barbiturates ranged from 0.20 to 0.33 ng/mL, and the calculated sensitivity improvement ranged from 868‐ to 1700‐fold. The experimental results revealed excellent linearity (R2 > 0.99), with relative standard deviations of 2.1%–3.4% for the migration time and 4.3%–5.7% for the peak area. The recoveries of the spiked serum samples were 97.1% –110.3%. Our proposed approach offers a rapid and practical method for quantifying barbiturates in biological fluids. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Dispersive liquid-liquid microextraction combined with acetonitrile stacking through capillary electrophoresis for the determination of three selective serotonin reuptake inhibitor drugs in body fluids

Author

Ming-Mu Hsieh, En-Ping Lin, and Tai-Chia Chiu

Subjects
Detection limit, Analyte, Chromatography, 010401 analytical chemistry, Extraction (chemistry), Stacking, Filtration and Separation, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Solvent, chemistry.chemical_compound, Electrophoresis, Capillary electrophoresis, chemistry, 0210 nano-technology, Acetonitrile
Abstract

Dispersive liquid-liquid microextraction was combined with acetonitrile stacking in capillary electrophoresis for the identification of three selective serotonin reuptake inhibitors (citalopram, fluoxetine, and fluvoxamine) in human fluids such as urine and plasma. Parameters that affect the extraction and stacking efficiency, such as the type and volume of the extraction and disperser solvent, extraction time, salt addition for dispersive liquid-liquid microextraction, and sample matrices, pH, and concentration of the separation buffer for stacking, were investigated and optimized. Under optimum conditions, the enrichment factors were in the range of 1195-1441. Limits of detection ranged from 1.4 to 1.7 nM for the target analytes. Calibration graphs displayed satisfied linearity with R2 greater than or equal to 0.9978, and relative standard deviations of the peak area analysis were in the range of 2.9-5.0% (n = 3). The recoveries of all tricyclic antidepressant drugs from urine and plasma were in the range of 77-117 and 79-106%, respectively. The findings of this study show that dispersive liquid-liquid microextraction acetonitrile-stacking capillary electrophoresis is a rapid and convenient method for identifying tricyclic antidepressant drugs in urine and plasma.

Published
2016
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3. Dispersive liquid-liquid microextraction combined with acetonitrile stacking through capillary electrophoresis for the determination of three selective serotonin reuptake inhibitor drugs in body fluids

Author

En-Ping, Lin, Tai-Chia, Chiu, and Ming-Mu, Hsieh

Subjects
Acetonitriles, Liquid Phase Microextraction, Electrophoresis, Capillary, Humans, Selective Serotonin Reuptake Inhibitors
Abstract

Dispersive liquid-liquid microextraction was combined with acetonitrile stacking in capillary electrophoresis for the identification of three selective serotonin reuptake inhibitors (citalopram, fluoxetine, and fluvoxamine) in human fluids such as urine and plasma. Parameters that affect the extraction and stacking efficiency, such as the type and volume of the extraction and disperser solvent, extraction time, salt addition for dispersive liquid-liquid microextraction, and sample matrices, pH, and concentration of the separation buffer for stacking, were investigated and optimized. Under optimum conditions, the enrichment factors were in the range of 1195-1441. Limits of detection ranged from 1.4 to 1.7 nM for the target analytes. Calibration graphs displayed satisfied linearity with R

Published
2016

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