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Your search keyword '"Macchioni, L."' showing total 4 results
Start Over Author "Macchioni, L." Journal journal of rheumatology
4 results on '"Macchioni, L."'

1. Intercellular adhesion molecule-1 gene polymorphisms in Behçet's Disease.

Author

Boiardi, L, Salvarani, C, Casali, B, Olivieri, I, Ciancio, G, Cantini, F, Salvi, F, Malatesta, R, Govoni, M, Trotta, F, Filippini, D, Paolazzi, G, Nicoli, D, Farnetti, E, and Macchioni, L

Abstract

OBJECTIVE: Intercellular adhesion molecule 1 (ICAM-1) is strongly expressed in vascular endothelial cells and perivascular inflammatory infiltrates in immunopathologic studies of Behçet's disease (BD) lesions. ICAM-1 genes may contribute to the inflammatory events responsible for the vessel damage in BD. We examined potential associations of ICAM-1 gene polymorphisms with BD susceptibility. METHODS: Case patients were 74 consecutive Italian patients with BD who were followed at the Bologna, Ferrara, Milano, Potenza, Prato, Reggio Emilia, and Trento rheumatology, ophthalmology, and neurology units over a 3 year period (1997-99) who satisfied the International Study Group criteria for BD; 228 healthy Italian blood donors from the same geographic areas were selected as control groups. All BD patients and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for ICAM-1 polymorphisms at codon 241 (exon 4) and codon 469 (exon 6). RESULTS: The frequency of R241 was significantly higher in BD patients than in controls (20.3% vs 5.7%; p = 0.001, pcorr = 0.002, OR 4.2, 95% CI 1.9-9.3). The distribution of E/K 469 genotype was similar in patients and controls. Comparing patients with different clinical features, we found only a trend to higher frequency of R241 in patients with articular manifestations (21.4% vs 12.5%; p = 0.08). CONCLUSION: Our findings show that G/R 241 polymorphism of ICAM-1 is associated with BD susceptibility.

Published
2001

2. Shoulder ultrasonography in the diagnosis of polymyalgia rheumatica: a case-control study.

Author

Cantini, F, Salvarani, C, Olivieri, I, Niccoli, L, Padula, A, Macchioni, L, Boiardi, L, Ciancio, G, Mastrorosato, M, Rubini, F, Bozza, A, and Zanfranceschi, G

Abstract

OBJECTIVE: Magnetic resonance imaging (MRI) showed that subacromial/subdeltoid bursitis is the most frequent shoulder lesion in polymyalgia rheumatica (PMR). We evaluated whether shoulder ultrasonography (US) was as effective as MRI in the detection of this lesion and assessed the sensitivity and specificity of bilateral subacromial/subdeltoid bursitis in the diagnosis of PMR. METHODS: A case-control study of 57 consecutive case patients with untreated PMR and 114 controls seen over a 6 month period in 3 secondary referral rheumatology centers. Control patients consisted of the next 2 consecutive patients with bilateral shoulder aching and stiffness observed after the case patient. In all case and control patients the glenohumeral joint space, bursae, and long head biceps tendon were assessed by bilateral shoulder US. The first 24 case patients were also examined by bilateral shoulder MRI. RESULTS: US showed subacromial/subdeltoid bursitis in 55/57 (96%) patients with PMR and in 25/114 (22%) controls (p < 0.001). The lesion was bilateral in 53/55 (96%) case patients and in 1/25 (4%) controls (p < 0.001). The frequency of glenohumeral joint synovitis and biceps tenosynovitis did not differ significantly between case patients and controls. In 100% of case patients MRI showed subacromial/subdeltoid bursitis confirming US findings. The sonographic evidence of bilateral bursitis had a sensitivity of 92.9%, specificity of 99. 1%, and positive predictive value of 98. 1% for the diagnosis of PMR. CONCLUSION: US and MRI were equally effective in confirming bilateral subacromial and subdeltoid bursitis in PMR. This finding, in view of its high sensitivity and specificity, could be used as a new diagnostic criterion for PMR.

Published
2001

3. Corticosteroid injections in polymyalgia rheumatica: a double-blind, prospective, randomized, placebo controlled study.

Author

Salvarani C, Cantini F, Olivieri I, Barozzi L, Macchioni L, Boiardi L, Niccoli L, Padula A, Pulsatelli L, and Meliconi R

Subjects
Aged, Aged, 80 and over, Bursitis diagnosis, Bursitis drug therapy, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Methylprednisolone administration & dosage, Methylprednisolone Acetate, Placebos, Polymyalgia Rheumatica diagnosis, Prospective Studies, Shoulder Joint, Synovitis diagnosis, Synovitis drug therapy, Tendinopathy diagnosis, Tendinopathy drug therapy, Treatment Outcome, Anti-Inflammatory Agents administration & dosage, Methylprednisolone analogs & derivatives, Polymyalgia Rheumatica drug therapy
Abstract

Objective: To determine the efficacy and safety of shoulder corticosteroid injections in polymyalgia rheumatica (PMR)., Methods: Twenty consecutive patients with active PMR were randomized into a 7 month, double blind, placebo controlled study. Patients received either bilateral shoulder injections of 40 mg of 6-methylprednisolone acetate or placebo (1 ml saline solution). Responders were treated weekly with the same regimen for a total of 4 bilateral injections and then followed for 6 months. Response was defined as a 70% reduction in visual analog scale (VAS) score for pain and for patient and physician global assessment, and duration of morning stiffness. Bilateral shoulder magnetic resonance imaging (MRI) was performed at different times to evaluate the response of lesions to therapy., Results: All 10 corticosteroid treated patients responded to the first injection with a significant reduction in duration of morning stiffness, VAS pain scale, patient and physician global assessment, erythrocyte sedimentation rate, and C-reactive protein. Interleukin 6 serum levels were significantly reduced after the 2nd injection. In 5 patients, the response persisted throughout the followup period. The other 5 withdrew within 4 weeks after the 4th injection due to recurrence of symptoms. None of the 10 patients of the placebo group responded to the first injection. The difference between the 2 groups was significant (p = 0.03). No side effects were recorded. MRI showed marked improvement of shoulder lesions one week after first injection and an almost complete resolution one week after last injection in the responders., Conclusion: Shoulder corticosteroid injections seem to be an effective and safe therapy for PMR.

Published
2000

4. Distal extremity swelling with pitting edema in psoriatic arthritis: evidence of 2 pathological mechanisms.

Author

Salvarani C, Cantini F, Olivieri I, Niccoli L, Senesi C, Macchioni L, Boiardi L, and Padula A

Subjects
Adult, Arthritis, Psoriatic diagnosis, Arthritis, Psoriatic diagnostic imaging, Edema diagnosis, Female, Hand diagnostic imaging, Hand pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Tenosynovitis diagnosis, Tenosynovitis diagnostic imaging, Tenosynovitis etiology, Arthritis, Psoriatic physiopathology, Edema etiology
Abstract

Distal extremity swelling with pitting edema due to altered lymphatic drainage has been reported in some patients with psoriatic arthritis (PsA). The edema usually affected the upper limbs in an asymmetric pattern and was resistant to therapy. We describe 2 additional cases. The distal swelling and pitting edema responded promptly and completely to corticosteroids in the first patient but persisted in the second. Lymphoscintigraphy and magnetic resonance imaging (MRI) revealed a predominant tenosynovitis in the hand without lymphedema in the first patient, and impaired lymphatic drainage without tenosynovial sheath involvement in the second. We conclude that 2 different mechanisms, characterized by a different response to therapy, may be associated with the same clinical picture of distal swelling with pitting edema in patients with psoriatic arthritis. Lymphoscintigraphy and MRI are useful in defining the structures involved and in predicting the prognosis.

Published
1999

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