1. Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis
- Author
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Ali Akoum, Nathalie Bourcier, Françoise Naud, Rodolphe Maheux, Mahera Al-Akoum, and Christine Lawson
- Subjects
medicine.medical_specialty ,Immunology ,Endometriosis ,In situ hybridization ,Interleukin 1 receptor, type II ,Choristoma ,Interleukin-1 receptor ,Biology ,Endometrium ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Receptors, Interleukin-1 Type II ,RNA, Messenger ,Receptors, Interleukin-1 Type I ,Obstetrics and Gynecology ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Reproductive Medicine ,In utero ,Female ,Interleukin 1 receptor, type I ,Cell activation - Abstract
Interleukin-1 (IL1) is believed to play a central role in the immuno-inflammatory process associated with endometriosis. IL1 triggers cell activation via its receptor type I (IL1R1), but its receptor type II (IL1R2) is known instead as a scavenger that buffers the cytokine's effects. Our previous studies have shown increased expression of IL1R1 in active endometriotic implants compared to normal and endometriosis women-derived endometrial tissues, and a simultaneous decrease in IL1R2 expression at the protein level. In the present study, in situ hybridization demonstrated a noticeable decrease in IL1R2 mRNA hybridization score in eutopic and matched ectopic endometrial tissues of women with endometriosis compared to normal women in the stroma (P
- Published
- 2008