1. Effect of acute transcranial magnetic stimulation on intracellular signalling in human skeletal muscle
- Author
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Henrik Kjellgren, Nerrolyn Ramstrand, Eva Pontén, Jessica Norrbom, Nils von Wachenfelt, Eva-Karin Gidlund, Björn Alkner, Chang Liu, Ferdinand von Walden, and Carl Johan Sundberg
- Subjects
Adult ,Male ,electromyography ,medicine.medical_specialty ,Fysiologi ,Anabolism ,Physiology ,Vastus lateralis muscle ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,Stimulation ,RM1-950 ,Electromyography ,Internal medicine ,transcranial magnetic stimulation ,skeletal muscle ,anabolic signalling ,muscle wasting ,Humans ,Medicine ,Muscle, Skeletal ,Wasting ,medicine.diagnostic_test ,business.industry ,Rehabilitation ,AMPK ,Skeletal muscle ,General Medicine ,Transcranial magnetic stimulation ,Endocrinology ,medicine.anatomical_structure ,Female ,Therapeutics. Pharmacology ,medicine.symptom ,business ,human activities ,Signal Transduction - Abstract
Objective: To investigate the potential of an acute bout of transcranial magnetic stimulation to induce anabolic signalling. Design: Experimental intervention on healthy subjects. Subjects: Ten healthy subjects, 5 women and 5 men (mean age 32 years; standard deviation (SD) 4). Methods: Transcranial magnetic stimulation, resulting in contraction of the quadriceps muscles, was applied at a frequency of 10 Hz for 10 s followed by 20 s of rest, repeated 40 times over 20 min. Electromyography and force data were collected for all transcranial magnetic stimulation sequences. Muscle biopsies were obtained from the vastus lateralis muscle before and 1 and 3 h after stimulation for evaluation of the molecular response of the muscle. Results: The described stimulation decreased phosphorylation of AKT at Thr308 (1 h: -29%, 3 h: -38%; pFunding Agencies|Futurum - the Academy for Health and Care, Region Jonkoping County, Sweden; Swedish Society of Medicine
- Published
- 2020
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