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Objective: To evaluate the efficacy of immersive movement observation in adult patients with haemophilic ankle arthropathy. Design: Multicentre, single-blind, randomized clinical trial. Subjects: 48 patients with haemophilia. Methods: Patients were randomly allocated to 2 groups (180º immersive video-based visualization of movement and a control group with no intervention). Twenty-eight consecutive 15-min home sessions, 1 per day, of immersive visualization of ankle flexion–extension movement were carried out. Three evaluations were performed: pretreatment (T0), post-intervention (T1), and at 16 weeks’ follow-up (T2). The primary variable was joint-pain intensity (visual analogue scale). The secondary variables were conditioned pain modulation (Conditioned Pain Modulation Index), pressure pain threshold (pressure algometer), range of motion (goniometry) and kinesiophobia (Tampa Scale of Kinesiophophia). Results: There were intergroup differences in pain intensity (F = 37.14; p