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Existing knowledge of the geopolitics of public health and the coronavirus pandemic indicates that states, particularly the most powerful ones (the United States, China, Russia), have used the current global crisis to strengthen their influence worldwide, in line with their geopolitical, economic, and military aspirations. Geopoliticisation of the COVID-19 vaccines have not been explored so far. Based on the qualitative analysis of the media content and statistics on the vaccines' distribution, this article makes two arguments. First, these vaccines have become an extension of foreign policy by other means. Second, geopoliticisation of the distribution of vaccine contributes to an instrumentalisation of the pandemic, raising global insecurity and the destabilisation of states and economies on the periphery and semi-periphery. Due to this new Cold War between the 'vaccine superpowers' , the world has become divided into Western and the Eastern 'vaccine-blocs'. Within this context, the chances for multilateral cooperation to counter global threats are on a downward trajectory.