1. Medical radioisotope 89Zr production with RFT-30 cyclotron.
- Author
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Lee, Jun Young, Hur, Min Goo, Kong, Young Bae, Lee, Eun Je, Yang, Seung Dae, Choi, Pyeong Seok, and Park, Jeong Hoon
- Subjects
CYCLOTRONS ,RADIOISOTOPES ,POSITRON emission tomography ,NUCLEAR energy ,NUCLEAR research ,NUCLEAR medicine - Abstract
89 Zr is an emerging radionuclide with promising application in nuclear medicine for the non-invasive diagnosis of various cancers with PET imaging. This paper would discuss optimization efforts in the production of89 Zr carried out at Accelerator Radioisotope Development Team, Korea Atomic Energy Research Institute. Optimized conditions reveal high production yields of89 Zr ~ 37 ± 1.4 MBq/µA using89 Y(p,n)89 Zr, ~ 12.7 MeV of proton, and 35 µA using yttrium coin target with indigenously constructed 30 MeV Cyclotron (RFT-30). Besides, the production optimization, quality control, and biological behavior of [89 Zr]Zr-oxalate, chloride and, DFO demonstrated promising results. [ABSTRACT FROM AUTHOR]- Published
- 2021
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