Search

Green synthesis of metal nanoparticles (NPs) from plant extracts has attracted significant interest in modern medicine. therefore, this study prepared an aqueous extract of Sophora flavescens roots, which are used in folk medicine to treat several diseases, including bacterial infections. in addition, silver NPs (AgNPs) were synthesized from root extract using the green synthesis method. the NPs were diagnosed using modern methods. Additionally, the antibacterial activity of the root aqueous extract and AgNPs aqueous preparation (at concentrations of 7% and 9%, respectively) was examined against selected isolates of multidrug-resistant Pseudomonas aeruginosa and Staphylococcus aureus. the results indicated that both the plant extract and NP preparations inhibited pathogenic bacterial isolates. [ABSTRACT FROM AUTHOR]

The multifunctional features of noble metal nanoparticles (MNPs) were exploited in various biomedical applications, which eventually demanded the development of a sustainable green synthesis approach. In the present study, Quercetin (Q) was employed as a promising green reductant for the generation of noble metal nanoparticles such as silver (Q-AgNPs), gold (Q-AuNPs), and bimetallic (Q-Ag-AuNPs) towards biomedical perspective. Initially, the NPs were successfully synthesized in a size-controlled manner via optimizing temperature, pH, metal ion concentration, and stoichiometric ratio of the reaction mix. The redox reaction and conversion of metal ions (Ag+ and Au3+) into their respective metal nano-forms were confirmed through their surface plasmonic resonance (SPR) in UV-visible spectroscopy. In addition, different instrumentation like FT-IR, XRD, HR-TE M, and XPS analyses were performed to confirm the size, shape, and chemical composition of fabricated NPs. The bactericidal effect of fabricated NPs was tested against Gram-positive and Gram-negative pathogens. Moreover, the cytotoxic potential was screened against breast (MCF-7) and colorectal (HCT-116) carcinoma cell lines. This work revealed that the flavonoid-functionalized noble metal NPs were associated with good antibacterial and anticancer potential against selected cancer cell lines. [ABSTRACT FROM AUTHOR]