1. The impact of body mass index in gene expression of reelin pathway mediators in individuals with schizophrenia and mood disorders: A post-mortem study.
- Author
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Brietzke E, Trevizol AP, Fries GR, Subramaniapillai M, Kapczinski F, McIntyre RS, and Mansur RB
- Subjects
- Adult, Autopsy, Brain metabolism, Brain pathology, Cell Adhesion Molecules, Neuronal genetics, Extracellular Matrix Proteins genetics, Female, Humans, Male, Microarray Analysis, Middle Aged, Nerve Tissue Proteins genetics, RNA, Messenger metabolism, Reelin Protein, Serine Endopeptidases genetics, Statistics, Nonparametric, Body Mass Index, Cell Adhesion Molecules, Neuronal metabolism, Extracellular Matrix Proteins metabolism, Gene Expression physiology, Mood Disorders genetics, Mood Disorders metabolism, Mood Disorders pathology, Nerve Tissue Proteins metabolism, Schizophrenia genetics, Schizophrenia metabolism, Schizophrenia pathology, Serine Endopeptidases metabolism, Signal Transduction physiology
- Abstract
The objective of this study was to compare the expression of genes involved in the reelin pathway, in the post-mortem brain of individuals with schizophrenia (SZ) and mood disorders (MD) with a healthy control (HC) group; and to investigate the role f body mass index (BMI) as a potential mediator. The "Gene Expression in Postmortem dlPFC and Hippocampus from Schizophrenia and Mood Disorders" study holds microarray data on individuals with SZ, MD and HCs (from whom 849 specimens are from the dlPFC and 579 from the hippocampus). mRNA data was obtained using HumanHT-12 v4 BeadChip arrays (Illumina). Multivariate analysis of covariance were used to investigate the main effects of group and relevant covariates on RELNm, NOTCH1, GRIN1m, GRIN3A, CAMK2Gm, CAMK2A, CAMK2Bm, CAMK2N2, GRIN2Bm, GRIN2A, CREBBPm, APOE, LDLR and DAB1 gene expression. In the dlPFC, individuals with SZ had higher expression, relative to HCs, of APOE. Individuals with MD had higher expression, relative to HCs, of CAMK2A, CAMK2N2, and GRIN2Bm. Moreover, individuals with MD had higher expression, relative to SZ patients, of CAMK2N2. There were significant group by BMI effects for expression of RELN, CAMK2A, CAMK2N2, and GRIN2A. In the hippocampus, individuals with MD had lower expression, relative to HCs, of APOE. The results of this study suggest that the expression of genes related to the reelin pathway could be different between individuals with SZ and MD and healthy controls, with a greater vulnerability associated with greater BMI., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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