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Your search keyword '"Zhao, Aihua"' showing total 33 results
Start Over Author "Zhao, Aihua" Journal journal of proteome research
33 results on '"Zhao, Aihua"'

2. Global and Targeted Metabolomics Evidence of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats

Author

Zhao, Linjing, primary, Zhao, Aihua, additional, Chen, Tianlu, additional, Chen, Wenlian, additional, Liu, Jiajian, additional, Wei, Runmin, additional, Su, Jing, additional, Tang, Xuelan, additional, Liu, Keyi, additional, Zhang, Ran, additional, Xie, Guoxiang, additional, Panee, Jun, additional, Qiu, Mingfeng, additional, and Jia, Wei, additional

Published
2016
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4. Metabonomics Reveals Metabolite Changes in Biliary Atresia Infants

Author

Zhou, Kejun, primary, Xie, Guoxiang, additional, Wang, Jun, additional, Zhao, Aihua, additional, Liu, Jiajian, additional, Su, Mingming, additional, Ni, Yan, additional, Zhou, Ying, additional, Pan, Weihua, additional, Che, Yanran, additional, Zhang, Ting, additional, Xiao, Yongtao, additional, Wang, Yang, additional, Wen, Jie, additional, Jia, Wei, additional, and Cai, Wei, additional

Published
2015
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9. Serum Metabolic Signatures of Four Types of Human Arthritis

Author

Jiang, Miao, primary, Chen, Tianlu, additional, Feng, Hui, additional, Zhang, Yinan, additional, Li, Li, additional, Zhao, Aihua, additional, Niu, Xuyan, additional, Liang, Fei, additional, Wang, Minzhi, additional, Zhan, Junping, additional, Lu, Cheng, additional, He, Xiaojuan, additional, Xiao, Lianbo, additional, Jia, Wei, additional, and Lu, Aiping, additional

Published
2013
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10. Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer

Author

Tan, Binbin, primary, Qiu, Yunping, additional, Zou, Xia, additional, Chen, Tianlu, additional, Xie, Guoxiang, additional, Cheng, Yu, additional, Dong, Taotao, additional, Zhao, Linjing, additional, Feng, Bo, additional, Hu, Xiaofang, additional, Xu, Lisa X., additional, Zhao, Aihua, additional, Zhang, Menghui, additional, Cai, Guoxiang, additional, Cai, Sanjun, additional, Zhou, Zhanxiang, additional, Zheng, Minhua, additional, Zhang, Yan, additional, and Jia, Wei, additional

Published
2013
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11. Metabonomics Approach to Assessing the Modulatory Effects of St John’s Wort, Ginsenosides, and Clomipramine in Experimental Depression

Author

Wang, Xiaoyan, primary, Zeng, Chuiyu, additional, Lin, Jingchao, additional, Chen, Tianlu, additional, Zhao, Tie, additional, Jia, Zhiying, additional, Xie, Xie, additional, Qiu, Yunping, additional, Su, Mingming, additional, Jiang, Tao, additional, Zhou, Mingmei, additional, Zhao, Aihua, additional, and Jia, Wei, additional

Published
2012
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12. Transcriptomic and Metabonomic Profiling Reveal Synergistic Effects of Quercetin and Resveratrol Supplementation in High Fat Diet Fed Mice

Author

Zhou, Mingmei, primary, Wang, Shidong, additional, Zhao, Aihua, additional, Wang, Ke, additional, Fan, Ziquan, additional, Yang, Hongzhou, additional, Liao, Wen, additional, Bao, Si, additional, Zhao, Linjing, additional, Zhang, Yinan, additional, Yang, Yongqing, additional, Qiu, Yunping, additional, Xie, Guoxiang, additional, Li, Houkai, additional, and Jia, Wei, additional

Published
2012
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13. Metabolic Fate of Tea Polyphenols in Humans

Author

Xie, Guoxiang, primary, Zhao, Aihua, additional, Zhao, Linjing, additional, Chen, Tianlu, additional, Chen, Huiyuan, additional, Qi, Xin, additional, Zheng, Xiaojiao, additional, Ni, Yan, additional, Cheng, Yu, additional, Lan, Ke, additional, Yao, Chun, additional, Qiu, Mingfeng, additional, and Jia, Wei, additional

Published
2012
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14. Distinct Urinary Metabolic Profile of Human Colorectal Cancer

Author

Cheng, Yu, primary, Xie, Guoxiang, additional, Chen, Tianlu, additional, Qiu, Yunping, additional, Zou, Xia, additional, Zheng, Minhua, additional, Tan, Binbin, additional, Feng, Bo, additional, Dong, Taotao, additional, He, Pingang, additional, Zhao, Linjing, additional, Zhao, Aihua, additional, Xu, Lisa X., additional, Zhang, Yan, additional, and Jia, Wei, additional

Published
2011
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15. The Footprints of Gut Microbial–Mammalian Co-Metabolism

Author

Zheng, Xiaojiao, primary, Xie, Guoxiang, additional, Zhao, Aihua, additional, Zhao, Linjing, additional, Yao, Chun, additional, Chiu, Norman H. L., additional, Zhou, Zhanxiang, additional, Bao, Yuqian, additional, Jia, Weiping, additional, Nicholson, Jeremy K., additional, and Jia, Wei, additional

Published
2011
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16. Metabolic Signature of Pregnant Women with Neural Tube Defects in Offspring

Author

Zheng, Xiaoying, primary, Su, Mingming, additional, Pei, Lijun, additional, Zhang, Ting, additional, Ma, Xu, additional, Qiu, Yunping, additional, Xia, Hongfei, additional, Wang, Fang, additional, Zheng, Xiaojiao, additional, Gu, Xue, additional, Song, Xinming, additional, Li, Xin, additional, Qi, Xin, additional, Chen, Gong, additional, Bao, Yihua, additional, Chen, Tianlu, additional, Chi, Yi, additional, Zhao, Aihua, additional, and Jia, Wei, additional

Published
2011
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18. Serum and Urinary Metabonomic Study of Human Osteosarcoma

Author

Zhang, Zhiyu, primary, Qiu, Yunping, additional, Hua, Yingqi, additional, Wang, Yihuang, additional, Chen, Tianlu, additional, Zhao, Aihua, additional, Chi, Yi, additional, Pan, Li, additional, Hu, Shuo, additional, Li, Jian, additional, Yang, Chengwei, additional, Li, Guodong, additional, Sun, Wei, additional, Cai, Zhengdong, additional, and Jia, Wei, additional

Published
2010
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19. Urinary Metabonomic Study on Colorectal Cancer

Author

Qiu, Yunping, primary, Cai, Guoxiang, additional, Su, Mingming, additional, Chen, Tianlu, additional, Liu, Yumin, additional, Xu, Ye, additional, Ni, Yan, additional, Zhao, Aihua, additional, Cai, Sanjun, additional, Xu, Lisa X., additional, and Jia, Wei, additional

Published
2010
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25. Global and Targeted Metabolomics Evidence of the Protective Effect of Chinese Patent Medicine Jinkui ShenqiPill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats

Author

Zhao, Linjing, Zhao, Aihua, Chen, Tianlu, Chen, Wenlian, Liu, Jiajian, Wei, Runmin, Su, Jing, Tang, Xuelan, Liu, Keyi, Zhang, Ran, Xie, Guoxiang, Panee, Jun, Qiu, Mingfeng, and Jia, Wei

Abstract

Glucocorticoids are commonly used in anti-inflammatory and immunomodulatory therapies, but glucocorticoid withdrawal can result in life-threatening risk of adrenal insufficiency. Chinese patented pharmaceutical product Jinkui Shenqipill (JKSQ) has potent efficacy on clinical adrenal insufficiency resulting from glucocorticoid withdrawal. However, the underlying molecular mechanism remains unclear. We used an animal model to study JKSQ-induced metabolic changes under adrenal insufficiency and healthy conditions. Sprague–Dawley rats were treated with hydrocortisone for 7 days with or without 15 days of JKSQ pretreatment. Sera were collected after 72 h hydrocortisone withdrawal and used for global and free fatty acids (FFAs)-targeted metabolomics analyses using gas chromatography/time-of-flight mass spectrometry and ultraperformance liquid chromatography/quadruple time-of-flight mass spectrometry. Rats without hydrocortisone treatment were used as controls. JKSQ pretreatment normalized the significant changes of 13 serum metabolites in hydrocortisone-withdrawal rats, involving carbohydrates, lipids, and amino acids. The most prominent effect of JKSQ was on the changes of FFAs and some [product FFA]/[precursor FFA] ratios, which represent estimated desaturase and elongase activities. The opposite metabolic responses of JKSQ in adrenal insufficiency rats and normal rats highlighted the “Bian Zheng Lun Zhi” (treatment based on ZHENG differentiation) guideline of TCM and suggested that altered fatty acid metabolism was associated with adrenal insufficiency after glucocorticoid withdrawal and the protective effects of JKSQ.

Published
2016
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30. Serum metabolic signatures of fulminant type 1 diabetes.

Author

Lu J, Zhou J, Bao Y, Chen T, Zhang Y, Zhao A, Qiu Y, Xie G, Wang C, Jia W, and Jia W

Subjects
Adult, Amino Acids metabolism, Analysis of Variance, Biomarkers blood, Biomarkers metabolism, Case-Control Studies, Diabetes Mellitus, Type 1 metabolism, Female, Glutathione biosynthesis, Humans, Male, Middle Aged, Principal Component Analysis, Diabetes Mellitus, Type 1 blood, Metabolomics methods
Abstract

Fulminant type 1 diabetes (FT1DM) is a relatively new clinical entity featured by acute destruction of pancreatic beta cells. Clinical consequences of FT1DM could be fatal when timely medications are not provided, suggesting the particular importance of rapid and accurate diagnosis. Here we report a serum metabonomics study of FT1DM patients, together with healthy control subjects (NC), type 2 diabetes (T2DM), classic type 1 diabetes (T1DM), and diabetic ketoacidosis (DKA) patients, with the aim of discovering metabolic markers associated with FT1DM. A total of 79 subjects were enrolled (22 NC, 22 T1DM, 22 T2DM, 8 DKA and 5 FT1DM) and the serum metabolic profiling of fasting blood samples was performed using gas chromatography time-of-flight mass spectrometry (GC-TOFMS) coupled with multivariate and univariate statistical analyses. Serum metabolites differentially expressed in FT1DM relative to NC, or to T2DM, T1DM and DKA were identified. Three metabolite markers, 5-oxoproline, glutamate, and homocysteine, were significantly altered among FT1DM, T2DM, T1DM, and DKA. In addition, the three metabolite markers, 5-oxoproline, glutamate, and homocysteine, presented similar patterns of distribution across groups. The results showed that the metabolic signatures of FT1DM identified in this study could be of potential clinical significance for the accurate diagnosis of FT1DM.

Published
2012
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31. Distinct urinary metabolic profile of human colorectal cancer.

Author

Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, and Jia W

Subjects
Adult, Aged, Aged, 80 and over, Area Under Curve, Case-Control Studies, Chromatography, High Pressure Liquid, Colorectal Neoplasms metabolism, Female, Gas Chromatography-Mass Spectrometry, Humans, Least-Squares Analysis, Male, Metabolome, Middle Aged, Principal Component Analysis, ROC Curve, Biomarkers, Tumor urine, Colorectal Neoplasms urine, Metabolomics methods
Abstract

A full spectrum of metabolic aberrations that are directly linked to colorectal cancer (CRC) at early curable stages is critical for developing and deploying molecular diagnostic and therapeutic approaches that will significantly improve patient survival. We have recently reported a urinary metabonomic profiling study on CRC subjects (n = 60) and health controls (n = 63), in which a panel of urinary metabolite markers was identified. Here, we report a second urinary metabonomic study on a larger cohort of CRC (n = 101) and healthy subjects (n = 103), using gas chromatography time-of-flight mass spectrometry and ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry. Consistent with our previous findings, we observed a number of dysregulated metabolic pathways, such as glycolysis, TCA cycle, urea cycle, pyrimidine metabolism, tryptophan metabolism, polyamine metabolism, as well as gut microbial-host co-metabolism in CRC subjects. Our findings confirm distinct urinary metabolic footprints of CRC patients characterized by altered levels of metabolites derived from gut microbial-host co-metabolism. A panel of metabolite markers composed of citrate, hippurate, p-cresol, 2-aminobutyrate, myristate, putrescine, and kynurenate was selected, which was able to discriminate CRC subjects from their healthy counterparts. A receiver operating characteristic curve (ROC) analysis of these markers resulted in an area under the receiver operating characteristic curve (AUC) of 0.993 and 0.998 for the training set and the testing set, respectively. These potential metabolite markers provide a novel and promising molecular diagnostic approach for the early detection of CRC.

Published
2012
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32. Metabonomic evaluation of melamine-induced acute renal toxicity in rats.

Author

Xie G, Zheng X, Qi X, Cao Y, Chi Y, Su M, Ni Y, Qiu Y, Liu Y, Li H, Zhao A, and Jia W

Subjects
Acute Kidney Injury urine, Animals, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Food Contamination, Kidney anatomy & histology, Kidney drug effects, Kidney metabolism, Male, Multivariate Analysis, Organ Size, Principal Component Analysis, Rats, Rats, Wistar, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Acute Kidney Injury chemically induced, Acute Kidney Injury metabolism, Metabolomics methods, Triazines toxicity
Abstract

The recent outbreak of renal failure in infants in China has been determined to be caused by melamine (Mel) and derivatives adulterated in the food. A metabonomic study was performed to evaluate the global biochemical alteration triggered by Mel ingestion in parallel with the acute renal toxicity in rats. Mel at 600, 300, and 100 mg/kg, cyanuric acid (Cya) at 100 mg/kg, and mixture of Mel and Cya (50 mg/kg each) were administered in five groups of Wistar rats, respectively, via oral gavage for 15 days. Urinary metabonomic profiles indicated that Mel perturbed urinary metabolism in a dose-dependent manner, with high-dose group showing the most significant impact. Metabonomic variations also suggest that the toxicity of low-dose (50 mg/kg) Mel was greatly elevated by the presence of Cya (at 50 mg/kg), which was able to induce a significant metabolic alteration to a level equivalent to that of 600 mg/kg Mel. Histological examination and serum biochemical analysis also indicated that the low-dose Mel-Cya mixture and high-dose Mel group resulted in the greatest renal toxicity. The high-dose Mel and low-dose Mel-Cya resulted in disrupted amino acid metabolism including tryptophan, polyamine, and tyrosine metabolism, and altered TCA and gut microflora structure.

Published
2010
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33. Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS.

Author

Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, and Jia W

Subjects
Adult, Aged, Amino Acids metabolism, Female, Humans, Metabolic Networks and Pathways, Middle Aged, Statistics, Nonparametric, Urea metabolism, Colorectal Neoplasms blood, Gas Chromatography-Mass Spectrometry methods, Metabolome
Abstract

Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis and small-molecule metabolite production. We have performed a serum metabolic analysis to test the hypothesis that the distinct metabolite profiles of malignant tumors are reflected in biofluids. In this study, we have analyzed the serum metabolites from 64 colorectal cancer (CRC) patients and 65 healthy controls using gas chromatography time-of-flight mass spectrometry (GC-TOFMS) and Acquity ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (Acquity UPLC-QTOFMS). Orthogonal partial least-squares discriminate analysis (OPLS-DA) models generated from GC-TOFMS and UPLC-QTOFMS metabolic profile data showed robust discrimination from CRC patients and healthy controls. A total of 33 differential metabolites were identified using these two analytical platforms, five of which were detected in both instruments. These metabolites potentially reveal perturbation of glycolysis, arginine and proline metabolism, fatty acid metabolism and oleamide metabolism, associated with CRC morbidity. These results suggest that serum metabolic profiling has great potential in detecting CRC and helping to understand its underlying mechanisms.

Published
2009
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