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Objective To investigate the expression of WD repeat-containing protein 5 (WDR5) in cervical cancer tissue and its relationship with clinical pathological characteristics and prognosis of patients. Methods 105 CA patients admitted to our hospital from January 2018 to March 2020 were included as the study subjects, the cancer tissue and adjacent tissue samples of patients were collected, Immunohistochemical staining and Western blot were used to detect the level of WDR5 in CA tissue and adjacent cancer tissues. Immunohistochemistry and Western blot were used to determine the level; Survival analysis was conducted using the Kaplan Meier method; The influencing factors of patient prognosis were analyzed through Cox regression. Results Among 105 CA tissue samples, the positive expression rate of WDR5 (WDR5 positive cases/total cancer tissue cases) was 68.57% (72/105, which was higher than 22.86% (24/105) in adjacent cancer tissues (P < 0.05) ; Compared to adjacent tissues (1.00 ± 0.11, the expression level of WDR5 was higher in CA tissues (4.66 ± 0.98) (t = 38.030, P < 0.05 ). The expression level of WDR5 is related to the degree of differentiation, TNM staging, and lymph node metastasis (P < 0.05 ; The survival rate of WDR5 positive expression was 65.28% (47/72) lower than that of negative expression of 90.91% (30/33) (Log rank χ² = 6.732, P = 0.009) ; TNM staging, WDR5, degree of differentiation, and lymph node metastasis are all influencing factors for patient prognosis (P < 0.05 ). Conclusion The expression of WDR5 is elevated in cervical cancer tissues, and its changes are closely related to TNM staging, differentiation, lymph node metastasis, and prognosis in cervical cancer patients. [ABSTRACT FROM AUTHOR]