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The prospect of carrying out this study was to prepare and characterize an optimized polyvinylpyrrolidone (PVP)-poloxamer (PLX) hydrophilic polymeric blend for improved solubility of poorly water-soluble drugs. Levodropropizine (LDP) was used as a model drug in this research. Several LDP-loaded PVP-PLX formulations were fabricated via the solvent evaporation method, and tested for solubility and dissolution of LDP in water. Other physicochemical characterization was accomplished using X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Amongst all the formulations tested, the one composed of LDP, PVP and PLX at the ratio of 25/37.5/37.5 (w/w/w, %) gave the highest solubility (~ 470.96 ± 23.84 mg/ml) and dissolution (~ 95% in 15 min) of LDP in the aqueous media. Furthermore, LDP existed in the amorphous state in this formulation with no strong chemical interactions with the components of polymeric blend. The morphological investigations revealed that the particles of this formulation had irregular shapes and surfaces. Thus, the abovementioned optimized hydrophilic polymeric blend, composite or synergist might be a suitable oral delivery system for numerous other poorly water-soluble drugs as well.

The study was aimed to synthesize and characterize effective sustained release polymeric microspheres of sulfasalazine and dexamethasone by using okra gum and hydroxypropyl methylcellulose (HPMC). The solvent extraction technique was used to synthesize sulfasalazine and dexamethasone loaded okra gum/HPMC microspheres. Pods of Hibiscus esculentus was used to extract okra gum. FTIR, DSC and SEM studies were performed. Kinetic modeling were applied on dissolution release data to evaluate release pattern of drugs from prepared formulations. No interaction was observed between drug and polymers by FTIR study. Molecular dispersion of sulfasalazine and dexamethasone was observed by DSC studies. SEM analysis showed acceptable morphology of microsphere. Dissolution studies showed that drug release was retarded up to 8 h when Okra gum and HPMC were used in combination but contrarily, HPMC and Okra gum showed early release of drug when both were used alone. Okra gum/HPMC microspheres of sulfasalazine and dexamethasone were prepared triumphantly by solvent evaporation method. Recovery, entrapment effectiveness hydration and drug loading of microspheres, influenced by the concentrations of Okra gum/HPMC.