1. Improved Regeneration of Autologous Nerve Transplants by Means of VEGF-Gene Therapy
- Author
-
R. Milojcic, Moritz A. Konerding, Bernd Gansbacher, Hans-Guenther Machens, R. E. Giunta, T. Holzbach, Martina Anton, and T. Brill
- Subjects
medicine.medical_specialty ,Pathology ,biology ,business.industry ,Genetic enhancement ,Regeneration (biology) ,VEGF receptors ,Ischemia ,medicine.disease ,Spinal cord ,Neuroprotection ,Surgery ,Viral vector ,Vascular endothelial growth factor ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,medicine ,biology.protein ,business - Abstract
The impact of the Vascular Endothelial Growth Factor (VEGF) on the angiogenic cascade is proven. Recently its neuroprotective effect after peripheral nerve injuries on α-motoneurons in the spinal cord was shown. Experiments on α-motoneurons demonstrated a decreased sensitivity to ischemia under VEGF-therapy. Aim of the study was to elucidate the effect of a localized VEGF-gene-therapy using an adenoviral vector construct in the model of a peripheral nerve defect in the rat treated with an autologous nerve transplant.
- Published
- 2009
- Full Text
- View/download PDF