1. Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome
- Author
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José-Antonio Oteo, Emma Recio-Fernández, Patricia Pérez-Matute, Maria Jesus Villanueva-Millan, and José-Miguel Lezana Rosales
- Subjects
Adult ,Male ,0301 basic medicine ,Physiology ,Population ,HIV Infections ,030209 endocrinology & metabolism ,Inflammation ,Gut flora ,Biochemistry ,Deep sequencing ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,education ,Gene ,Metabolic Syndrome ,education.field_of_study ,Bacteria ,biology ,business.industry ,General Medicine ,biology.organism_classification ,medicine.disease ,Gastrointestinal Microbiome ,Gastrointestinal Tract ,030104 developmental biology ,Chronic Disease ,Immunology ,Dysbiosis ,Female ,medicine.symptom ,Metabolic syndrome ,business - Abstract
The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies concerning GM have been performed in HIV-infected patients with MS. The aim of this study was to analyze bacterial translocation, inflammation, and GM composition in HIV-infected patients with and without MS. A total of 51 HIV-infected patients were recruited and classified according to the presence of MS (40 patients without MS and 11 with MS). Markers of bacterial translocation, inflammation, and cardiovascular risk were measured and GM was analyzed using 16S rRNA gene deep sequencing. No differences were observed among both HIV-infected groups in the bacterial translocation markers LBP and sCD14. A tendency to increase the inflammatory markers IL-6 (p = 0.069) and MCP-1 (p = 0.067) was observed in those patients suffering from MS. An increase in the cardiovascular risk markers PAI-1 (p = 0.007) and triglycerides/HDL cholesterol ratio (p
- Published
- 2019