1. Intraoperative hyperspectral label-free imaging: from system design to first-in-patient translation
- Author
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Iain Yardley, Philipp Führnstahl, Sebastien Ourselin, Eli Nabavi, José Miguel Spirig, Tom Vercauteren, Shakeel R Saeed, Yijing Xie, Mazda Farshad, Robert Bradford, Jonathan Shapey, Armando Hoch, A. David Edwards, Michael Ebner, Florentin Liebmann, University of Zurich, and Vercauteren, Tom
- Subjects
Paper ,medicine.medical_specialty ,3104 Condensed Matter Physics ,Acoustics and Ultrasonics ,hyperspectral imaging ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Special Issue on Translational Biophotonics ,610 Medicine & health ,DIAGNOSIS ,01 natural sciences ,Physics, Applied ,010309 optics ,03 medical and health sciences ,0302 clinical medicine ,first-in-patient ,0103 physical sciences ,Visual assessment ,3102 Acoustics and Ultrasonics ,Computer-Assisted Intervention ,medicine ,TECHNOLOGY ,Medical physics ,In patient ,Label free ,exoscope ,Science & Technology ,medical device ,Physics ,2508 Surfaces, Coatings and Films ,2504 Electronic, Optical and Magnetic Materials ,Hyperspectral imaging ,computer assisted interventions ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Workflow ,translational research ,Physical Sciences ,Imaging technology ,Systems design ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,030217 neurology & neurosurgery - Abstract
Despite advances in intraoperative surgical imaging, reliable discrimination of critical tissue during surgery remains challenging. As a result, decisions with potentially life-changing consequences for patients are still based on the surgeon's subjective visual assessment. Hyperspectral imaging (HSI) provides a promising solution for objective intraoperative tissue characterisation, with the advantages of being non-contact, non-ionising and non-invasive. However, while its potential to aid surgical decision-making has been investigated for a range of applications, to date no real-time intraoperative HSI (iHSI) system has been presented that follows critical design considerations to ensure a satisfactory integration into the surgical workflow. By establishing functional and technical requirements of an intraoperative system for surgery, we present an iHSI system design that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two systems exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were designed and investigated by performing assessments against established design criteria and ex vivo tissue experiments. Finally, we report the use of our real-time iHSI system in a clinical feasibility case study as part of a spinal fusion surgery. Our results demonstrate seamless integration into existing surgical workflows., Journal of Physics D: Applied Physics, 54 (29), ISSN:0022-3727, ISSN:1361-6463
- Published
- 2021