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1. Membrane environment reduces the accessible conformational space available to an integral membrane protein

Author

Gerken, Uwe, Jelezko, Fedor, Gotze, Britta, Branschadel, Marcus, Tietz, Carsten, Ghosh, Robin, and Wrachtrup, Jorg

Subjects
Conformational analysis -- Usage, Chemistry, Physical and theoretical -- Research, Lipids -- Research, Membrane proteins -- Research, Chemicals, plastics and rubber industries
Abstract

The influence exerted on an integral membrane protein by its environment using the light-harvesting complex (LHI) of purple bacteria as a model, is studied. It is concluded that membrane environment significantly narrows the statistical distribution of conformational states available to the LH1 complex in comparison to the corresponding state distribution observed for the same detergent-solubilized protein.

Published
2003

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