Search

The two-state BT model, that considers the possibility of redistribution of population from the force-free bound state to the force stabilized bound state, is used to investigate the energy landscape underlying the catch-slip transition. The model correctly predicts the absence of catch bonds in the binding dynamics of antibodies to selectins and is used to solve to energy landscape parameters characterizing adhesive interactions of P- and L-selectin complexes with sPSGL-I and endoglycan and the antibody DREG56.

A novel path is described for assembling the hybrid materials containing the inorganic polymeric Si-O network and organic polymeric chains. The photoluminescence properties of these materials have shown that the ternary rare-earth/inorganic/organic polymeric hybrids present stronger luminescent intensities and higher luminescent quantum efficiencies than the binary rare-earth/inorganic polymeric hybrids.

A computational examination of the nature of the interaction between the affinity ligand and the agarose support to which it was bound through spacers of varying length and chemical nature is done through molecular dynamics. It is demonstrated that a change in the spacer properties could decide a change of the stable structure of the ligand with respect to the support and that if a support is not held fixed through restraints, the interaction forces between vicinal ligands will determine a major conformational change of the system.