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Start Over Author "Ford, James" Journal journal of pharmacy and pharmacology
20 results on '"Ford, James"'

12. The assay and stability of chlorpropamide in solid dispersion with urea

Author

Ford, James L, Stewart, Alan F, and Rubinstein, Michael H

Abstract

Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide-urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p-chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57·1 kJmol−1for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics.

Published
1979
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13. The effect of composition and ageing on the dissolution rates of chlorpropamide-urea solid dispersions

Author

Ford, James L and Rubinstein, Michael H

Abstract

Discs of chlorpropamide and urea have been prepared by (a) melting and (b) compression. Intrinsic and relative dissolution rates of the discs have been measured and the dissolution process investigated microscopically. Higher dissolution rates were found from melts than from physical mixes. The optimum dissolution rate composition found was for a melt composed of 30% w/w chlorpropamide which possessed an intrinsic dissolution rate 930 times greater than for the pure drug. Sphere formation, during dissolution rate measurement has been observed and a likely mechanism proposed to account for its occurrence. Dissolution rates generally increased with age for most melt compositions.

Published
1977
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14. Pharmaceutics: The Effects of Lag‐time and Dwell‐time on the Compaction Properties of 1:1 Paracetamol/microcrystalline Cellulose Tablets Prepared by Pre‐compression and Main Compression

Author

AKANDE, OLONIYON F., FORD, JAMES L., ROWE, PHILIP H., and RUBINSTEIN, MICHAEL H.

Abstract

The effects of lag‐time and dwell‐time on the compaction properties of tablets compressed from a 1:1 blend of paracetamol and microcrystalline cellulose have been examined using a compaction simulator.

Published
1998
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