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Your search keyword '"Izumi, Yasukatsu"' showing total 22 results
Start Over Author "Izumi, Yasukatsu" Journal journal of pharmacological sciences
22 results on '"Izumi, Yasukatsu"'

19. A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-4

Author

Yamaguchi, Takehiro, Watanabe, Ayano, Tanaka, Masako, Shiota, Masayuki, Osada-Oka, Mayuko, Sano, Soichi, Yoshiyama, Minoru, Miura, Katsuyuki, Kitajima, Shojiro, Matsunaga, Shinji, Tomita, Shuhei, Iwao, Hiroshi, and Izumi, Yasukatsu

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors not only improve impaired glucose tolerance in diabetes, but also have pleiotropic extra-pancreatic effects such as preconditioning effect for myocardial ischemia-reperfusion injury. Here, we investigated the anti-remodeling effects of linagliptin, a DPP-4 inhibitor, by use of DPP-4-deficient rats.

Published
2024
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21. Beneficial Effect of Candesartan on Rat Diastolic Heart Failure

Author

Wake, Ryotaro, primary, Kim-Mitsuyama, Shokei, additional, Izumi, Yasukatsu, additional, Yoshida, Kaoru, additional, Izumiya, Yasuhiro, additional, Yukimura, Tokihito, additional, Shiota, Masayuki, additional, Yoshiyama, Minoru, additional, Yoshikawa, Junichi, additional, and Iwao, Hiroshi, additional

Published
2005
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22. Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig.

Author

Yamaguchi T, Yamazaki T, Kawaguchi H, Tawa M, Nakamura Y, Shiota M, Osada-Oka M, Tanimoto A, Okamura T, Miura K, Iwao H, Yoshiyama M, and Izumi Y

Subjects
Animals, Atherosclerosis etiology, Blood Pressure drug effects, Cardiomegaly chemically induced, Cholesterol, Dietary adverse effects, Coronary Vessels drug effects, Drug Discovery, Endothelium, Vascular physiology, Lipoproteins, LDL blood, Male, Muscle Relaxation drug effects, Muscle, Smooth, Vascular drug effects, NG-Nitroarginine Methyl Ester administration & dosage, NG-Nitroarginine Methyl Ester adverse effects, Nitric Oxide Synthase antagonists & inhibitors, Swine, Cholesterol, Dietary administration & dosage, Diet, High-Fat adverse effects, Disease Models, Animal, Metabolic Syndrome drug therapy, Metabolic Syndrome etiology, Metabolic Syndrome physiopathology, Swine, Miniature
Abstract

Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.

Published
2014
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