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Your search keyword '"Drieu A"' showing total 48 results
Start Over Author "Drieu A" Journal journal of pharmacological and toxicological methods
48 results on '"Drieu A"'

7. HYPNOS: A new software for EEG-mediated Assessment of drug-induced changes in sleep macrostructures in the rat

Author

Geoffrey Viardot, Philippe L'Hostis, Emilie Cayre, Simon Loiodice, Anne-Sophie Denibaud, Christophe Drieu La Rochelle, and Bertrand Rion

Subjects
Pharmacology, Drug, Software, medicine.diagnostic_test, business.industry, media_common.quotation_subject, medicine, Electroencephalography, Toxicology, business, Sleep in non-human animals, Neuroscience, media_common
Published
2018
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17. Assessment of drug-induced cardiovascular effects by telemetry in group-housed cynomolgus monkeys

Author

kevin-Sebastien Coquelin, Eric Delpy, Christophe Drieu-la-Rochelle, Anne-Marie Betat, and Fabrice Infanti

Subjects
Pharmacology, Drug, Low stress, medicine.medical_specialty, business.industry, media_common.quotation_subject, Safety pharmacology, Sotalol, Hemodynamics, Toxicology, Moxifloxacin, Telemetry, Internal medicine, Animal welfare, medicine, Cardiology, business, media_common, medicine.drug
Abstract

In conclusion, high quality cardiovascular telemetry recording is now possible in non-human primates pair-housed in large cages, therefore complying with the new directive 2010/63/UE. The new housing facilities and experimental conditions (including clicker-training method) result in very low stress, as demonstrated by behavioral observations and baseline haemodynamic parameters. This leads to excellent animal welfare and a strong basis for good science. Furthermore, the cardiovascular effects obtained with two compounds known to prolong ventricular repolarization in humans (moxifloxacin and sotalol) validate these conditions for use in safety pharmacology studies according to ICH S7A and S7B guidelines. DSI Transceiver TRX-1

Published
2014
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20. The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity

Author

D. Morillon, Valerie Bertaina-Anglade, C. Drieu La Rochelle, and E. Enjuanes

Subjects
Male, Drug-Related Side Effects and Adverse Reactions, Scopolamine, Muscarinic Antagonists, Motor Activity, Toxicology, Task (project management), Rats, Sprague-Dawley, Mice, Memory, medicine, Animals, Hypnotics and Sedatives, Learning, Pharmacology, Diazepam, Alprazolam, Dose-Response Relationship, Drug, business.industry, Safety pharmacology, Cognitive neuroscience of visual object recognition, Cns function, Recognition, Psychology, Memory retention, Rats, Mice, Inbred C57BL, Disease Models, Animal, Data Interpretation, Statistical, Artificial intelligence, Amnesia, business, Neuroscience, Psychomotor Performance, medicine.drug
Abstract

Introduction The aim of the present study was to evaluate the potential usefulness of the object recognition learning paradigm to detect the potential amnesic properties of a new drug for use in the characterisation of its safety pharmacology profile. Methods and Results In the first experiment, the time-dependent decay of object recognition memory was characterised in Sprague–Dawley rats and C57Bl/6J mice. Under our experimental conditions, it takes between 3 and 4 post-training hours for the rats and between 1 and 2 post-training hours for the mice to forget the respective value of the objects. In the second experiment, the effects of scopolamine (0.03–1 mg/kg) were investigated in both rats and mice when administered 30 min prior to training in the object recognition task. Memory retention was tested 2 h after training in rats and 1 h after training in mice. Scopolamine impairs the object recognition memory at doses of 0.1, 0.3, and 1 mg/kg in rats and at doses of 0.3 and 1 mg/kg in mice. In the last experiment, effects of two benzodiazepines (alprazolam and diazepam) were assessed in the mouse model of object recognition task. Diazepam and alprazolam were intraperitoneally administered 30 min prior to training and memory retention was tested 10 min and 1 h after training. At 0.2 mg/kg, both benzodiazepines impair object recognition memory when testing is performed 1 h after training. However, when testing is performed 10 min after training, both benzodiazepines at 0.2 mg/kg failed to disrupt memory processes. Discussion Taken together, these results show that the object recognition task can easily be performed in rats and mice for safety pharmacology studies related to CNS function. Because of the ageing population and the increasing number of drugs prescribed to elderly patients, it becomes important to evaluate the potential side effects of a new chemical entity on memory function during evaluation of its safety profile. The object recognition task, which is simple, rapid, and reliable, should be of great use in safety pharmacology to detect amnesic properties of new compounds.

Published
2006

43. The use of whole body plethysmography to evaluate drug-induced changes in respiratory disorders: Sleep apneas, cough and bronchospasm

Author

Mathilde Loiseau, Eric Delpy, Christophe Drieu La Rochelle, and Fabrice Infanti

Subjects
Pharmacology, Drug, Whole Body Plethysmography, business.industry, media_common.quotation_subject, Toxicology, Sleep in non-human animals, Bronchospasm, Sleep and breathing, Anesthesia, medicine, Respiratory system, medicine.symptom, business, media_common
Published
2010
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