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A method is proposed for the determination of the morphine content of opium and paregoric. The method combines extractive and spectrophotometric procedures and results in a substantial saving of time when compared to most existing methods. Results thus far obtained indicate that the method is sufficiently accurate for routine analyses.

The quantitative determination of morphine in paregoric by reversed-phase high-pressure liquid chromatography is described. The method is simple, accurate, and fast compared to the USP method. Benzoic acid in paregoric also can be determined quantitatively with the same column. The method was applied to two commercial samples with excellent results.