1. Liquiritin-Hydroxypropyl-Beta-Cyclodextrin Inclusion Complex: Preparation, Characterization, Bioavailability and Antitumor Activity Evaluation.
- Author
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Wang, Qilong, Zhang, Kangyi, Weng, Wen, Chen, Lin, Wei, Chunmei, Bao, Rui, Adu-Frimpong, Michael, Cao, Xia, Yu, Qingtong, Shi, Feng, Toreniyazov, Elmurat, Ji, Hao, Xu, Ximing, and Yu, Jiangnan
- Subjects
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BIOAVAILABILITY , *INCLUSION compounds , *ANTINEOPLASTIC agents , *SCANNING electron microscopes , *DIFFERENTIAL scanning calorimetry , *DRUG solubility , *AQUEOUS solutions , *INFRARED radiation - Abstract
The pharmacological activities of liquiritin (LT) are greatly limited by its insolubility and low oral absorption. The purpose of this study was to prepare LT-hydroxypropyl-beta-cyclodextrin inclusion complex (LT-HP-β-CD) to increase water solubility, oral bioavailability and antitumor effect of LT. Herein, saturated aqueous solution method was applied to prepare the LT-HP-β-CD prior to characterization via scanning electron microscope (SEM), infrared radiation (IR) spectroscopy, X-ray diffraction analysis (XRD), and differential scanning calorimetry (DSC). Also, in vitro release and in vivo pharmacokinetics were evaluated. Moreover, the anti-tumor activity of the formulation was investigated in the A549 lung cancer cells. The results of SEM, IR, XRD and DSC showed that LT-HP-β-CD was successfully formulated. In vitro release and oral bioavailability of LT-HP-β-CD compared with the free LT was significantly higher. Successfully, antitumor effect of LT was remarkably enhanced by the preparation of LT-HP-β-CD. Altogether, the LT-HP-β-CD represents a potential carrier for enhancing the water solubility and oral bioavailability of LT coupled with antitumor activity enhancement. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
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