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Objective: When confronted with major threats, people often experience decline in well‐being. The central purpose of this study was to identify mechanisms underlying change of well‐being in times of threat, using the example of the COVID‐19 pandemic, with a focus on appraisals of the pandemic and affective states, stress, as well as mindfulness in daily life. Method: We conducted a study across 3.5 weeks, including pretest, posttest, and a diary phase in‐between. We worked with a sample of 460 adults, pre‐ and post‐test information, as well as 7,189 observations from the diary phase. Results: Results showed that deterioration in mental health symptoms across the duration of the study was associated with (a) change towards less fortunate appraisals of the pandemic and (b), more negative affect and less mindfulness in daily life. Furthermore, appraisals of the pandemic at pretest predicted experiences in daily life, with more negative appraisals of the pandemic predicting more negative affect and stressor occurrence as well as less mindfulness. Conclusions: These findings speak to the dynamic nature of well‐being and appraisals in times of threat, and highlight the role of experiences in daily life in changes in well‐being. [ABSTRACT FROM AUTHOR]