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Your search keyword '"Prenatal Diagnosis"' showing total 2 results
Start Over Descriptor "Prenatal Diagnosis" Topic diagnosis of down syndrome Topic medical screening Journal journal of perinatal medicine
2 results on '"Prenatal Diagnosis"'

1. Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies.

Author

Cuckle, Howard, Heinonen, Seppo, Anttonen, Anna-Kaisa, and Stefanovic, Vedran

Subjects
*ULTRASONIC imaging of the uterus, *DIAGNOSIS of Down syndrome, *PRENATAL diagnosis, *MEDICAL screening, *MEDICAL care costs, *COST control, *DESCRIPTIVE statistics, *EXTRACELLULAR space, *BLOOD testing, *DIAGNOSTIC errors, *ENDOWMENTS, *GOVERNMENT aid, *NUCLEIC acids, *FETAL ultrasonic imaging, *BLOOD
Abstract

The article focuses on study of financial analysis is carried out to assess costs and benefits of providing cell-free DNA screening in Finland, using different strategies. Topics discussed include considering the place of cell-free DNA screening it is important to make explicit the additional and marginal costs of different screening strategies and the associated benefits; and most assumptions the balance is favorable for Contingent screening.

Published
2022
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2. Comparison of risk calculation approaches in a screening programme for Down syndrome.

Author

Koster, Maria P.h., Heetkamp, Kirsten M., De Miranda, Esteriek, and Schielen, Peter C.j.i.

Subjects
*MEDICAL screening, *DIAGNOSTIC services, *HEALTH risk assessment, *DIAGNOSIS of Down syndrome, *PRENATAL diagnosis, *DIAGNOSIS of fetal diseases, *COMPUTER network resources, *DOWN syndrome, *RISK assessment, *STATISTICS, *COMMUNITY-based social services, *INTER-observer reliability, *RECEIVER operating characteristic curves, *PREVENTION
Abstract

In the Netherlands, both the LifeCycle Elipse (LC) and the Astraia software package are used to calculate the risk of having a child with Down syndrome. Therefore, pregnant women can be presented with dissimilar risks. In this study the conformity between these risks before and after harmonization of the screening program and its influence on the performance indicators of the first trimester screening were evaluated. The agreement between combined risks (based on the biochemical parameters PAPP-A and fβ-hCG and a nuchal translucency measurement) was expressed as intraclass correlation coefficient (ICC)=0.99. Conformity between combined risks was better after harmonization (Cohen's κ=0.75) than before harmonization (Cohen's κ=0.63). For both risk calculation software packages the area under the ROC-curve was 0.84. The database contained 42 Down syndrome cases; based on the odds of being affected given a positive result (OAPR), LC performed slightly better than Astraia before harmonization (17.9 vs. 21.5, respectively). It has been acknowledged that using different software packages could lead to dissimilar risk calculations. In this study the screening performance indicators of two software packages were quite similar. The agreement of the screening performance after harmonization remains to be seen, but is expected to be even higher. [ABSTRACT FROM AUTHOR]

Published
2012
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