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1. Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia.

Author

Inder T, Mocatta T, Darlow B, Spencer C, Senthilmohan R, Winterbourn CC, and Volpe JJ

Subjects
Biomarkers, Female, Humans, Infant, Newborn, Leukomalacia, Periventricular microbiology, Leukomalacia, Periventricular pathology, Magnetic Resonance Imaging, Meningitis, Bacterial complications, Infant, Premature, Leukomalacia, Periventricular cerebrospinal fluid, Lipid Peroxidation, Meningitis, Bacterial cerebrospinal fluid, Oxidative Stress
Abstract

Free radicals have been hypothesized to play a key role in the evolution of periventricular leukomalacia, although direct evidence of oxidative injury in the human infant is lacking. This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis.

Published
2002
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