3 results on '"Claudio Giorlandino"'
Search Results
2. False-positive rate in prenatal diagnosis of surgical anomalies
- Author
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Antonio Zaccara, Antonella Nahom, Pietro Bagolan, Lucia Aite, A. Trucchi, Claudio Giorlandino, and Alessandro Borsellino
- Subjects
medicine.medical_specialty ,Prenatal diagnosis ,Sensitivity and Specificity ,Ultrasonography, Prenatal ,Congenital Abnormalities ,Abdominal wall ,Pregnancy ,medicine ,Humans ,False Positive Reactions ,Prospective cohort study ,Retrospective Studies ,Gynecology ,Gastroschisis ,business.industry ,Obstetrics ,Infant, Newborn ,Congenital diaphragmatic hernia ,Retrospective cohort study ,General Medicine ,medicine.disease ,Bowel obstruction ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Surgery ,Female ,business ,Follow-Up Studies - Abstract
Background/Purpose Technical refinements and increasingly sophisticated equipment have led to higher sensitivity in prenatal diagnosis of congenital malformations; however, such progress may be accompanied by decreased specificity. The aim of this study is to evaluate evolution of prenatal diagnosis from the first sonographic suspicion of fetal anomaly until after delivery (diagnosis confirmed, resolution before birth, healthy baby, or affected with different disorder) to document rate of false-positive (FP) results. Methods Retrospective review of prenatal ultrasound examinations performed at our institution between 2000 and 2002 was conducted. The series includes pregnancies referred to our department after detection of thoracic and abdominal anomalies at routine obstetrical sonography and with a follow-up comprising at least the first 6 months of life. Urologic malformations were excluded. Those fetuses who proved healthy at birth were considered FP results. Results One hundred fifty-seven fetuses/neonates underwent complete follow-up. Prenatal diagnosis of esophageal atresia resulted in 3 (27%) of 11 FPs. Finding of dilated bowel, isolated or associated with hyperechogenicity or ascites, was not predictive of small bowel obstruction in 7 (41%) of 17 fetuses. No FPs were found with regard to abdominal wall defects (8 gastroschisis and 26 omphaloceles, all confirmed at birth). Concerning thoracic malformations, no FPs were seen among the 28 cases of congenital diaphragmatic hernia, whereas diagnosis of lung malformation presented a specificity of 97% (1/28 FP). Ovarian cysts accounted for an FP rate of 17% (4/23 FPs). Overall, a percentage of FP of 12% (6/50) was seen in 2000, of 11% (5/44) in 2001, and 9% (6/63) in 2002, with no statistically significant difference. Conclusions Because of the high FP rate regarding some particular anomalies, unnecessary psychological burden to prospective parents may ensue. This issue should be dealt with in future prospective studies.
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- 2006
3. The management of fetal ovarian cysts
- Author
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V. Spina, Claudia Gatti, Elena Bilancioni, Pietro Bagolan, Antonella Nahom, A. Trucchi, Claudio Giorlandino, and V. Aleandri
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medicine.medical_specialty ,Torsion Abnormality ,medicine.medical_treatment ,Prenatal diagnosis ,Asymptomatic ,Ultrasonography, Prenatal ,Pregnancy ,medicine ,Humans ,Cyst ,Ovarian Diseases ,Prospective Studies ,Prospective cohort study ,business.industry ,Ovarian torsion ,Oophorectomy ,General Medicine ,medicine.disease ,Surgery ,Fetal Diseases ,Ovarian Cysts ,Treatment Outcome ,Inhalation ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,Complication - Abstract
Background/Purpose: Ovarian torsion causing the loss of an ovary represents the most common complication of fetal ovarian cysts and occurs more frequently before than after birth. Thus, treatment of fetal simple ovarian cysts should be performed antenatally; however, criteria for prenatal decompression still need to be evaluated. Previous experience of the authors showed that large simple cysts have a poor outcome, whereas preliminary attempts of their "in utero" aspiration were all successful and uneventful. The authors evaluated the outcome of fetal simple ovarian cysts after prenatal aspiration and considered criteria for this procedure. The outcome of cysts showing a prenatal ultrasound pattern of torsion also was studied. Methods: This prospective study includes 73 ovarian cysts (48 simple, 25 showing torsion) diagnosed in 72 fetuses from June 1992 to June 1999, and followed up until spontaneous resolution or surgery. Prenatal aspiration was performed in the case of simple cysts ≥5 cm in diameter. The outcome of these cysts was compared with that of similar cysts not aspirated in the authors' previous study (X 2 ). 10 Cysts with an US pattern of torsion persisting at birth were operated on. The outcome of simple cysts less than 5 cm and cysts with a prenatal ultrasound appearance of torsion also was evaluated. Results: Prenatal decompression was performed without any complications in 14 cases: 12 (86%; 95% CI: 0.68 to 1.00) regressed subsequently; 2 (14%; 95% CI: 0.00 to 0.32) showed torsion postnatally. This outcome is significantly better than that of similar cysts not aspirated in the authors' previous study 10 ( P =.0002). Among the 34 simple cysts less than 5 cm, 26 (76%; 95% CI: 0.62 to 0.90) resolved spontaneously; 8 (24%; 95% CI: 0.10 to 0.38) had complications, 7 of which showing torsion (diameter at evidence of torsion, 4.4 cm [median]; range, 3.3 to 5.2 cm). Among the 34 cysts showing torsion (25 with initial US pattern of torsion + 9 subsequently complicated simple cysts), 24 (71%; 95% CI: 0.56 to 0.86) required oophorectomy; 9 (26%; 95% CI: 0.11 to 0.41) spontaneously disappeared at ultrasound, one of which required surgery for intestinal obstruction secondary to adhesion of a necrotic ovary; one patient (3%; 95% CI: 0.00 to 0.09) was lost to follow-up. Conclusions: Prenatal aspiration of ovarian cysts appears effective and safe: a "cutoff" of 4 cm should be investigated. Cysts with ultrasound pattern of torsion persisting postnatally require surgery; options for their management, when sonographically disappearing and asymptomatic, need to be investigated. J Pediatr Surg 37:25-30. Copyright © 2002 by W.B. Saunders Company.
- Published
- 2002
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