1. Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?
- Author
-
Alexander Spratt, Anthony J Vivian, and Tim Key
- Subjects
musculoskeletal diseases ,Hla testing ,Adolescent ,Human leukocyte antigen ,Bacille Calmette Guerin ,medicine.disease_cause ,Polymerase Chain Reaction ,Functional Laterality ,medicine ,Humans ,Tuberculosis ,skin and connective tissue diseases ,Alleles ,business.industry ,Molecular Mimicry ,Vaccination ,General Medicine ,HLA-DR Antigens ,medicine.disease ,Uveitis, Anterior ,Ophthalmology ,Molecular mimicry ,Rheumatoid arthritis ,Pediatrics, Perinatology and Child Health ,Immunology ,Chronic Disease ,Chronic anterior uveitis ,BCG Vaccine ,Female ,business ,Uveitis ,HLA-DRB1 Chains - Abstract
A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette–Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1*0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.
- Published
- 2008