1. Recovery of ovarian function and pregnancy in a patient with AML after myeloablative busulphan-based conditioning regimen
- Author
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Pavel Trakhtman, Tatiana A. Nazarenko, Dmitry Balashov, Anna V. Andriutsa, Alexei Maschan, Nino A. Revishvili, Alexander Rumiantsev, Marina I. Persiantseva, Y.V. Skvortsova, E V Skorobogatova, and Ludmila Papusha
- Subjects
medicine.medical_specialty ,Transplantation Conditioning ,Acute myeloblastic leukemia ,Adolescent ,medicine.medical_treatment ,Antineoplastic Agents ,Hematopoietic stem cell transplantation ,Young Adult ,Hypergonadotropic hypogonadism ,Pregnancy ,hemic and lymphatic diseases ,medicine ,Humans ,Vaginal bleeding ,Child ,Busulfan ,Chemotherapy ,business.industry ,Hypogonadism ,Ovary ,Hematopoietic Stem Cell Transplantation ,Pregnancy Outcome ,Hematology ,Recovery of Function ,Myeloablative Agonists ,medicine.disease ,Combined Modality Therapy ,Surgery ,Leukemia, Myeloid, Acute ,surgical procedures, operative ,Oncology ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
We report a rare case of ovarian function recovery and pregnancy after hormone-replacement therapy (HRT) in the acute myeloblastic leukemia (AML) patient in third complete remission received hematopoietic stem cell transplantation (HSCT) with busulphan-based conditioning regimen. Successful engraftment of the donor cells and full donor's chimerism was achieved without the signs of leukemia. One year after HSCT the patient received a course of HRT as a treatment of hypergonadotropic hypogonadism. After 12 months of HRT the recovery of ovarian function was confirmed. Eight years after the HSCT spontaneous pregnancy occurred; heartbeat of the fetus was registered on week 7. Three weeks later a nonsevere vaginal bleeding occurred and the ultrasound examination showed a nondeveloping pregnancy. Genetic examination of the abortion material showed a full triploid genotype (69 XXX). To our knowledge this is a first case of ovarian function restoration and spontaneous pregnancy in a AML patient after multiple courses of high-dose chemotherapy and busulphan-based myeloablative conditioning for HSCT.
- Published
- 2011