1. Hepatoblastoma in a Mosaic Trisomy 18 Patient
- Author
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K. H. Ramesh, Rosanna Ricafort, Michelle Ewart, Elaine Maria Pereira, Jane S. Kim, and Robert W. Marion
- Subjects
Hepatoblastoma ,medicine.medical_specialty ,Pediatrics ,Conservative management ,medicine.medical_treatment ,Disease free ,Trisomy ,medicine ,Humans ,Favorable outcome ,Child ,Chemotherapy ,Mosaicism ,business.industry ,Liver Neoplasms ,Remission Induction ,Cytogenetics ,Karyotype ,Hematology ,medicine.disease ,digestive system diseases ,Oncology ,Pediatrics, Perinatology and Child Health ,Female ,Chromosomes, Human, Pair 18 ,business - Abstract
We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.
- Published
- 2012