1. Case Report of a Massive Life-threatening Neonatal Thrombosis Treated With a Targeted, Goal-oriented Scheme of Urokinase
- Author
-
Alessandra Rossi, Elena Ciarmoli, Paolo Villani, Gabriele Saldi, and Maria Pierro
- Subjects
C-Reactive Protein ,Oncology ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Humans ,Infant ,Thrombolytic Therapy ,Thrombosis ,Hematology ,Goals ,Procalcitonin ,Urokinase-Type Plasminogen Activator - Abstract
Thrombotic events are severe, often under-diagnosed, complications occurring in newborn infants during their hospital stay. Currently, there is no consensus regarding the optimal treatment scheme for thrombolysis in neonates.We present the case of a newborn suffering from a life-threatening thrombosis. Diagnosis was suggested by a gradual increase of C-reactive protein, with repeatedly normal procalcitonin. Thrombosis was successfully and safely treated with a long scheme of 21 days of urokinase, supported by vascular ultrasound and d-dimer trend.Laboratory and ultrasound results may help in adjusting the duration of the thrombolytic treatment, allowing for longer therapeutic schemes that could optimize treatment success. In addition, our case may suggest a possible combined role of C-reactive protein and procalcitonin as an early diagnostic aid in neonatal thrombosis.
- Published
- 2021