1. Effect of cholesterol deprivation on piglet small intestine and serum lipids.
- Author
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Engelhardt EL, Sankar M, Wu-Wang CY, Thomas MR, Walker WR, and Neu J
- Subjects
- Analysis of Variance, Animals, Female, Hydroxymethylglutaryl CoA Reductases metabolism, Intestine, Small enzymology, Lipids blood, Liver enzymology, Male, Microvilli metabolism, Random Allocation, Sex Factors, Swine, Weight Gain, Animals, Newborn metabolism, Cholesterol deficiency, Cholesterol, Dietary administration & dosage, Food Deprivation physiology, Intestine, Small metabolism, Lipid Metabolism
- Abstract
Using the neonatal piglet, the effects of dietary cholesterol deprivation on growth, intestinal enzyme activity, intestinal and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and serum lipid were studied. Six litters of piglets were randomly assigned to one of two feeding regimens: restricted (800 ml of formula/24 h) versus unrestricted (1,200 ml of formula/24 h). Within litters, piglets were separated by sex, then randomly assigned to a formula containing low cholesterol (less than 2 mg/dl) or high cholesterol (145 mg/dl). Piglets were fed for 2 weeks. Male piglets in the restricted low cholesterol group gained significantly less weight per milliliter of formula than the restricted high cholesterol males. No effect was observed in the females. Microvillus membrane lactase activity was greater in males fed a high versus low cholesterol diet. Intestinal and hepatic HMG-CoA reductase activities and serum lipid profiles showed a trend toward compensation for dietary cholesterol deprivation but did not differ statistically between the cholesterol-fed versus -deprived groups. It is concluded that dietary cholesterol deprivation in the male neonatal pig causes alterations in growth, but no other statistically significant responses were detectable in this study.
- Published
- 1991
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