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Your search keyword '"David J. Mitchell"' showing total 3 results
Start Over Author "David J. Mitchell" Journal journal of pediatric gastroenterology and nutrition
3 results on '"David J. Mitchell"'

1. Incidence of Paediatric Stricturing Duodenal Crohn Disease: A 19-Year Population-based Cohort Study

Author

C Burgess, Philip Hammond, Paul Henderson, David C. Wilson, David J. Mitchell, and Peter M. Gillett

Subjects
Male, Pediatrics, medicine.medical_specialty, Abdominal pain, Adolescent, Constriction, Pathologic, Cohort Studies, 03 medical and health sciences, Lethargy, 0302 clinical medicine, Crohn Disease, 030225 pediatrics, medicine, Humans, Prospective Studies, Duodenal Diseases, Prospective cohort study, Child, business.industry, Incidence (epidemiology), Medical record, Incidence, Gastroenterology, Scotland, Pediatrics, Perinatology and Child Health, Cohort, 030211 gastroenterology & hepatology, Female, medicine.symptom, Complication, business, Cohort study
Abstract

OBJECTIVES Stricturing duodenal Crohn disease (CD) is a rare but serious presentation of CD causing significant morbidity. We aim to provide the first robust incidence data and case studies on this severe presentation in children. METHODS A regional cohort of prospectively acquired incident cases of paediatric CD diagnosed

Published
2019
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2. Neonatal enteropathies: defining the causes of protracted diarrhea of infancy

Author

David J. Mitchell, Ernest Cutz, and Philip M. Sherman

Subjects
Male, medicine.medical_specialty, Polyhydramnios, Microvillous inclusion disease, Autoimmune enteropathy, Gastroenterology, Severity of Illness Index, Autoimmune Diseases, Internal medicine, medicine, Humans, Enteropathy, Intestinal Mucosa, Inclusion Bodies, Pregnancy, Microvilli, business.industry, digestive, oral, and skin physiology, Infant, Newborn, Infant, IPEX syndrome, medicine.disease, Congenital tufting enteropathy, Immunohistochemistry, Infant Nutrition Disorders, Diarrhea, Pediatrics, Perinatology and Child Health, Chronic Disease, Diarrhea, Infantile, Female, medicine.symptom, business, Food Hypersensitivity
Abstract

The underlying causes of chronic diarrhea beginning early in life are increasingly well defined. Infectious and post-infectious enteropathies and food sensitive/allergic enteropathy account for the majority of cases. Recent attention has focused on characterizing defined entities, which cause protracted diarrhea in infants and young children. Disorders of intestinal ion transport usually present at birth following a pregnancy complicated by polyhydramnios. Intestinal mucosal biopsies show normal architect with intact villus-crypt axis. Neonatal enteropathies, by contrast, are characterized by blunting of the villi. These include microvillus inclusion disease, tufting enteropathy, autoimmune enteropathy and IPEX syndrome - and it is these conditions that are the subject of the current review.

Published
2003

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