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Your search keyword '"McClean A"' showing total 27 results
Start Over Author "McClean A" Journal journal of pediatric gastroenterology & nutrition
27 results on '"McClean A"'

1. Liver Failure in Early Infancy: Aetiology, Presentation, and Outcome

Author

Suzanne Davison, Rosemary Thwaites, Sanjay Rajwal, Patricia McClean, and Rana Bitar

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine.medical_treatment, digestive, oral, and skin physiology, Treatment outcome, Gastroenterology, Liver failure, Retrospective cohort study, Jaundice, Liver transplantation, Early infancy, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Etiology, Medicine, 030211 gastroenterology & hepatology, medicine.symptom, Presentation (obstetrics), business
Abstract

Objective:Acute liver failure (ALF) in early infancy is rare and challenging to recognize and manage. We aim to describe the presentation and outcome of infants with ALF according to their final aetiology to elucidate features to facilitate early recognition leading to prompt diagnosis and m

Published
2017

4. Multidisciplinary Management of Surgical Disorders of the Pancreas in Childhood

Author

William Ramsden, Paddy McClean, Suzanne Davison, Maria B. Sheridan, Sanjay Rajwal, Mark D. Stringer, Helen Woodley, and John W L Puntis

Subjects
Male, Pediatrics, medicine.medical_specialty, Pancreatic disease, Adolescent, medicine.disease_cause, Disease-Free Survival, Pancreatectomy, medicine, Humans, Child, Hyperinsulinemic hypoglycemia, Pancreas, Pediatric gastroenterology, Retrospective Studies, Pancreatic duct, Pancreaticobiliary Malunion, business.industry, Gastroenterology, Infant, Pancreatic Diseases, medicine.disease, United Kingdom, Surgery, Pancreatic Neoplasms, Treatment Outcome, medicine.anatomical_structure, Pancreatitis, Child, Preschool, Acute Disease, Pediatrics, Perinatology and Child Health, Acute pancreatitis, Congenital Hyperinsulinism, Female, Pancreatic Cyst, business
Abstract

Objectives: To describe the frequency and range of pancreatic disorders in children requiring surgical intervention and to highlight the importance of multidisciplinary management. Methods: An audit of all children under 17 years of age referred with surgical disorders of the pancreas or pancreatitis to a regional pediatric gastroenterology unit in the United Kingdom during a 10-year period. A retrospective chart review of clinical features, pathology and outcome was undertaken. Results: Surgical intervention was required for the following pancreatic disorders: persistent hyperinsulinemic hypoglycemia of infancy (n = 4), pancreatic tumors (n = 5), pancreaticobiliary malunion (n = 12), pancreatic trauma (n = 6) and pancreatitis (n = 10). The indications for surgery in acute pancreatitis were a persistent pseudocyst (n = 1) and treatment of an underlying cause of pancreatitis (n = 4); in chronic pancreatitis, surgery was used to treat symptomatic pancreatic duct strictures (n = 4). One child died of a progressive lymphoma but all others who underwent surgery are alive and well. All 33 children with acute pancreatitis, including four with pancreatic necrosis, survived. Conclusions: Surgery for pancreatic disorders in children is rarely required but may be necessary a) for definitive management of primary pancreatic pathology, b) to treat sequelae of acute or chronic pancreatitis and c) to treat an underlying cause of pancreatitis. There is a broad spectrum of potential pathologies. These patients are best managed by a multidisciplinary team approach.

Published
2005

5. Liver Failure in Early Infancy

Author

Sanjay Rajwal, Suzanne Davison, and Patricia McClean

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Liver failure, Infant, Early infancy, 03 medical and health sciences, 0302 clinical medicine, Text mining, 030225 pediatrics, Pediatrics, Perinatology and Child Health, medicine, Hepatic Insufficiency, Humans, 030212 general & internal medicine, Intensive care medicine, business, Liver Failure
Published
2017

8. Congenital Hepatic Arterioportal Fistula

Author

M. D. Stringer, Patricia McClean, N D Heaton, John Karani, and G. Mieli-Vergani

Subjects
medicine.medical_specialty, business.industry, General surgery, Pediatrics, Perinatology and Child Health, Gastroenterology, medicine, Arterioportal fistula, business, Surgery
Published
1999

13. Endoscopic Rectal Sparing in Children With Untreated Ulcerative Colitis.

Author

Sanjay R. Rajwal, John W. L. Puntis, Patricia McClean, Suzanne M. Davison, Simon J. Newell, Ian Sugarman, and Mark D. Stringer

Abstract

SUMMARY: BACKGROUND Ulcerative colitis (UC) typically is associated with a confluent proctitis, whereas rectal sparing may be seen in large bowel Crohn disease (CD). A few studies have reported rectal sparing in UC and suggested that this might indicate a more severe form of the disease. This study aimed to determine the prevalence and prognostic significance of rectal sparing in children with newly diagnosed, untreated UC.METHODS The records of all children with untreated UC presenting to a regional pediatric gastroenterology service between January 1996 and December 2001 were retrospectively reviewed. Patients were divided into two groups according to the endoscopic appearance of the rectum: Group 1 (proctitis) and Group 2 (rectal sparing). Clinical features, intractability index (duration of active disease as a proportion of length of follow-up), response to treatment, relapse index (number of recurrences per year), and the need for surgery were compared.RESULTS Thirty children with untreated UC were identified. Seven (23%) had rectal sparing at initial endoscopy, but disease distribution was otherwise similar in both groups. Presenting symptoms were similar in those with and without rectal sparing. In Group 1, 20 (87%) children achieved remission with initial medical treatment, compared with 3 (43%) in Group 2 (P < 0.05). The intractability index was higher in children with rectal sparing, but the difference was not statistically significant (P = 0.22). During a median follow-up period of 2 years, one (4%) child in Group 1 and two (29%) children in Group 2 experienced primary sclerosing cholangitis, and two (29%) children with rectal sparing required colectomy, compared with none in Group 1.CONCLUSIONS Endoscopic rectal sparing was seen in 23% of children with newly diagnosed, untreated UC, but this feature did not correlate with presenting symptoms. However, the presence of rectal sparing may indicate more aggressive disease that is less responsive to medical treatment. [ABSTRACT FROM AUTHOR]

Published
2004
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18. Endoscopic Rectal Sparing in Children With Untreated Ulcerative Colitis

Author

Rajwal, Sanjay R., Puntis, John W. L., McClean, Patricia, Davison, Suzanne M., Newell, Simon J., Sugarman, Ian, and Stringer, Mark D.

Abstract

Ulcerative colitis (UC) typically is associated with a confluent proctitis, whereas rectal sparing may be seen in large bowel Crohn disease (CD). A few studies have reported rectal sparing in UC and suggested that this might indicate a more severe form of the disease. This study aimed to determine the prevalence and prognostic significance of rectal sparing in children with newly diagnosed, untreated UC. The records of all children with untreated UC presenting to a regional pediatric gastroenterology service between January 1996 and December 2001 were retrospectively reviewed. Patients were divided into two groups according to the endoscopic appearance of the rectum: Group 1 (proctitis) and Group 2 (rectal sparing). Clinical features, intractability index (duration of active disease as a proportion of length of follow-up), response to treatment, relapse index (number of recurrences per year), and the need for surgery were compared. Thirty children with untreated UC were identified. Seven (23%) had rectal sparing at initial endoscopy, but disease distribution was otherwise similar in both groups. Presenting symptoms were similar in those with and without rectal sparing. In Group 1, 20 (87%) children achieved remission with initial medical treatment, compared with 3 (43%) in Group 2 (P< 0.05). The intractability index was higher in children with rectal sparing, but the difference was not statistically significant (P= 0.22). During a median follow-up period of 2 years, one (4%) child in Group 1 and two (29%) children in Group 2 experienced primary sclerosing cholangitis, and two (29%) children with rectal sparing required colectomy, compared with none in Group 1. Endoscopic rectal sparing was seen in 23% of children with newly diagnosed, untreated UC, but this feature did not correlate with presenting symptoms. However, the presence of rectal sparing may indicate more aggressive disease that is less responsive to medical treatment.

Published
2004
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