1. Peripheral Precocious Puberty due to Functioning Adrenocortical Tumor: Description of Two Cases
- Author
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Valentino Cherubini, Lucia Ferrito, Cecilia Proietti Pannunzi, Giovanni Cobellis, Antonio Iannilli, and Diana Giobbi
- Subjects
Peripheral Precocious Puberty ,Pathology ,medicine.medical_specialty ,medicine.drug_class ,Adrenocortical Tumor ,Tumor resection ,Puberty, Precocious ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Precocious puberty ,Humans ,business.industry ,Virilization ,Obstetrics and Gynecology ,General Medicine ,Androgen ,medicine.disease ,Adrenal Cortex Neoplasm ,Virilism ,Adrenal Cortex Neoplasms ,030220 oncology & carcinogenesis ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
Background Adrenocortical tumors (ACTs) represent less than 0.2% of all childhood neoplasms. Frequent clinical manifestations are virilization, hypercortisolism, and peripheral precocious puberty (PPP). Cases We describe two cases in which ACTs were responsible for virilization (case 1) and PPP (case 2) in prepubertal girls. In both cases an ACT diagnosis was made after 5-6 months from the first appearance of clinical signs. Surgery was performed within 1 month of diagnosis, and the benign nature of tumors was histologically confirmed. Despite complete tumor resection, virilizing features persisted. Summary and Conclusions Adrenocortical tumors should be considered early in the assessment of PPP. There is often a significant delay between the onset of symptoms and accurate diagnosis but early treatment is essential to limit the clinical manifestations of androgen overproduction.
- Published
- 2016