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Start Over Author "Rouaud, Tiphaine" Journal journal of parkinson's disease
5 results on '"Rouaud, Tiphaine"'

1. Can Dopamine Responsiveness Be Predicted in Parkinson’s Disease Without an Acute Administration Test?

Author

Betrouni, Nacim, Moreau, Caroline, Rolland, Anne-Sophie, Carrière, Nicolas, Viard, Romain, Lopes, Renaud, Kuchcinski, Gregory, Eusebio, Alexandre, Thobois, Stephane, Hainque, Elodie, Hubsch, Cecile, Rascol, Olivier, Brefel, Christine, Drapier, Sophie, Giordana, Caroline, Durif, Franck, Maltête, David, Guehl, Dominique, Hopes, Lucie, Rouaud, Tiphaine, Jarraya, Bechir, Benatru, Isabelle, Tranchant, Christine, Tir, Melissa, Chupin, Marie, Bardinet, Eric, Defebvre, Luc, Corvol, Jean-Christophe, Devos, David, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Lille, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 (PLBS), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), CHU Marseille, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Service de Neurologie [CHU Nice], Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), CHU Bordeaux [Bordeaux], Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Amiens-Picardie, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), and Université de Picardie Jules Verne (UPJV)

Subjects
Antiparkinson Agents, Levodopa, Cellular and Molecular Neuroscience, Dopamine, [SCCO.NEUR]Cognitive science/Neuroscience, Humans, Parkinson Disease, Neurology (clinical), Magnetic Resonance Imaging
Abstract

Background: Dopamine responsiveness (dopa-sensitivity) is an important parameter in the management of patients with Parkinson’s disease (PD). For quantification of this parameter, patients undergo a challenge test with acute Levodopa administration after drug withdrawal, which may lead to patient discomfort and use of significant resources. Objective: Our objective was to develop a predictive model combining clinical scores and imaging. Methods: 350 patients, recruited by 13 specialist French centers and considered for deep brain stimulation, underwent an acute L-dopa challenge (dopa-sensitivity > 30%), full assessment, and MRI investigations, including T1w and R2* images. Data were randomly divided into a learning base from 10 centers and data from the remaining centers for testing. A machine selection approach was applied to choose the optimal variables and these were then used in regression modeling. Complexity of the modelling was incremental, while the first model considered only clinical variables, the subsequent included imaging features. The performances were evaluated by comparing the estimated values and actual values Results: Whatever the model, the variables age, sex, disease duration, and motor scores were selected as contributors. The first model used them and the coefficients of determination (R2) was 0.60 for the testing set and 0.69 in the learning set (p

Published
2022

2. Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications

Author

Devignes, Quentin, Daoudi, Sami, Viard, Romain, Lopes, Renaud, Betrouni, Nacim, Kuchcinski, Gregory, Rolland, Anne-Sophie, Moreau, Caroline, Defebvre, Luc, Bardinet, Eric, Bonnet, Marie, Brefel-Courbon, Christine, Delmaire, Christine, El Mountassir, Fouzia, Fluchère, Frédérique, Fradet, Anne, Giordana, Caroline, Hainque, Elodie, Houvenaghel, Jean-François, Jarraya, Béchir, Klinger, Hélène, Maltête, David, Marques, Ana, Meyer, Mylène, Rascol, Olivier, Rouaud, Tiphaine, Tir, Melissa, Wirth, Thomas, Corvol, Jean-Christophe, Devos, David, and Dujardin, Kathy

Abstract

Background: Parkinson’s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes.Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups.Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels.Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes.Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia.

Published
2022
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3. Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson’s Disease (PSYCHO-STIM II)

Author

Boussac, Mathilde, Arbus, Christophe, Klinger, Helene, Eusebio, Alexandre, Hainque, Elodie, Corvol, Jean Christophe, Rascol, Olivier, Rousseau, Vanessa, Harroch, Estelle, d’Apollonia, Charlotte Scotto, Croiset, Aurélie, Ory-Magne, Fabienne, De Barros, Amaury, Fabbri, Margherita, Moreau, Caroline, Rolland, Anne-Sophie, Benatru, Isabelle, Anheim, Mathieu, Marques, Ana-Raquel, Maltête, David, Drapier, Sophie, Jarraya, Béchir, Hubsch, Cécile, Guehl, Dominique, Meyer, Mylène, Rouaud, Tiphaine, Giordana, Bruno, Tir, Mélissa, Devos, David, and Brefel-Courbon, Christine

Abstract

Background: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson’s disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients’ quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN.Objective: To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN.Methods: DBS-STN-PD patients (n?=?303) having answered the “Temperament and Character Inventory” (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN.Results: Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p?

Published
2022
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4. Personality Dimensions Are Associated with Quality of Life in Fluctuating Parkinson's Disease Patients (PSYCHO-STIM).

Author

Boussac, Mathilde, Arbus, Christophe, Dupouy, Julia, Harroch, Estelle, Rousseau, Vanessa, Ory-Magne, Fabienne, Rascol, Olivier, Moreau, Caroline, Maltête, David, Rouaud, Tiphaine, Meyer, Mylène, Houvenaghel, Jean Francois, Marsé, Claire, Tranchant, Christine, Hainque, Elodie, Jarraya, Béchir, Ansquer, Solène, Bonnet, Marie, Belamri, Lhaouas, and Tir, Mélissa

Subjects
PARKINSON'S disease, DEEP brain stimulation, QUALITY of life, IMPULSE control disorders, PATIENT education
Abstract

Parkinson's disease (PD) negatively affects patients' Quality of Life (QoL) which depends on both objective criteria such as physical health and subjective ones such as worries and norms according to personal believes. Therefore, QoL could be also associated to personality dimensions in chronic neurological diseases such as PD. Objective: Our objective was thus to study the potential association between personality dimensions and QoL in PD patients with motor fluctuations before Deep Brain Stimulation of the Sub-Thalamic Nucleus (DBS-STN). Methods: Data were obtained from the French multicentric cohort study Predi-Stim. All PD patients awaiting DBS-STN and responding to the inclusion criteria at the time of the study were included. All participants answered the "Temperament and Character Inventory" (TCI) and the PDQ-39 before surgery. Analyses were made using adjusted univariate generalized linear regression models to evaluate a potential association between TCI dimensions and PDQ-39 scores. Results: Three hundred thirty-three consecutive patients were included. The temperament Harm Avoidance was negatively associated with QoL (p = 1e-4, R2= 0.33), whereas the character Self-Directedness was positively associated with mental component of QoL (p = 2e-4, R2= 0.33) in PD patients with motor fluctuations awaiting DBS-STN. Conclusions: PD patients with motor fluctuations, with lower Harm Avoidance and higher Self-Directedness scores have the best QoL mainly at an emotional and social level. Therapeutic education of these PD patients focusing on their personal resources may thus be important to improve their well-being. [ABSTRACT FROM AUTHOR]

Published
2020
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5. Colonic Neuropathology is Independent of Olfactory Dysfunction in Parkinson's Disease

Author

Lebouvier, Thibaud, primary, Pouclet, Hélène, additional, Coron, Emmanuel, additional, Drouard, Anne, additional, N'Guyen, Jean-Michel, additional, Roy, Monica, additional, Vavasseur, Fabienne, additional, Bruley des Varannes, Stanislas, additional, Damier, Philippe, additional, Neunlist, Michel, additional, Derkinderen, Pascal, additional, and Rouaud, Tiphaine, additional

Published
2011
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