1. The synthesis of biologically relevant conjugates of Re(CO)3 using pyridine-2-carboxyaldehyde
- Author
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Costa, Roshinee, Chanawanno, Kullapa, Engle, James T., Baroody, Bertha, Herrick, Richard S., and Ziegler, Christopher J.
- Subjects
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RHENIUM compounds synthesis , *PYRIDINE , *OXYALDEHYDES , *METAL complexes , *ANILINE derivatives , *SCHIFF bases - Abstract
Abstract: The new pyridine-2-carboxaldehyde adduct, Re(CO)3(NC6H5C(O)H)Cl 1, and previously reported complex Re(CO)3(NC6H5C(O)H)Br 2 react with aniline derivatives sulfanilamide or 4-aminofluorescein in methanol giving Schiff base conjugates Re(CO)3(pyca-R)X (pyca = pyridinecarbaldehyde imine, X = Cl, Br), 3–6. Pre-isolation of compounds 1 and 2 provides a convenient method for preparing conjugate complexes in addition to the known methods of ligand synthesis and one-pot reactions. All new compounds were completely characterized, and compound 1 and the sulfanilamide derivatives 3 and 4 were structurally elucidated by X-ray crystallography. [Copyright &y& Elsevier]
- Published
- 2013
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