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Research has been conducted on the optically active propargylic alcohols. The reaction of the alpha-carbanion derived from 2-(trimethylsilyl)vinyl sulfoxides with aldehydes has been investigated and the results indicate that it produces diastereomeric product mixture.

New and excellent carbonyl-face selective reactions of 2-formyl- and 2-acylnaphthalenes bearing the bulky (2,3,6-triisopropylphenyl)sulfinyl group, which can be performed without isolation of the disastereomeric rotamers are described. The removal of the sulfinyl group from the products would provide a convenient and efficient method for preparation of the optically active 2-naphthylalkanols.

Results reveal that p-tolyl alpha-lithio-beta-(trimethylsilyl)ethyl sulfoxide is a powerful chiral vinyl anion that is useful in the preparation of new chiral centers. Further, the p-tolyl alpha-lithio-beta-(trimethylsilyl)ethyl sulfoxide reacts with alpha,beta-unsaturated esters to form optically pure homoallylic carboxylates.

Research has been conducted on the reactions of alpha-sulfinyl carbanions with electrophiles. High stereoselectivity of the syn products of the reaction is discussed.

The enantioselective reaction of alpha-seleno carbanions derived from bis(phenylseleno)acetal and bis-(2-pyridylseleno)acetal in the presence of bis(oxazoline)s with various electrophiles gave products with high enantioselectivity. Mechanistic investigation reveals that the enantiodetermination of the reactions at -78 degree Celsius depends on dynamic thermodynamic resolution.

The study conducted to examine the enantioselective reaction of various alpha-lithiated dithioacetals with aldehydes or a ketone in the presence of bis(oxaline)s, is presented. With various aldehydes, an enantioselective reaction of a variety of lithiated dithioacetals is reported.

A peripherally substituted or unsubstituted phthalocyanines, having variety of metals is described by using a convenient synthesis. A novel synthesis of phthalocyanines directly from phtalimides and phthalic anhydride, by the action of hexamethyldisilazane (HMDS) under mild conditions, is reported.

Research has been conducted on p-tolyl 2-(trimethylsilyl)ethyl sulfoxide's alpha-carbanion. The reaction of this carbanion with esters and the following reduction with diisobutylaluminum hydride which produces highly stereoselective alpha-(trimethylsilyl)methyl-beta-ketosulfoxide is described.

The enantioselective reaction of α-seleno carbanions derived from bis(phenylseleno)acetal and bis(2-pyridylseleno)acetal in the presence of bis(oxazoline)s with various electrophiles gave products with high enantioselectivity. The enantioselective reaction of α-lithio benzyl 2-pyridyl selenide gave the products with stereochemistry reverse to that obtained in the reaction of α-lithio benzyl phenyl selenide. Mechanistic investigation suggests the enantiodetermination of these reactions at -78 °C depends on dynamic thermodynamic resolution. The enantioselective reaction was applied to the preparation of enantioenriched olefins and epoxide. [ABSTRACT FROM AUTHOR]

The enantioselective reaction of various α-lithiated dithioacetals with aldehydes or a ketone in the presence of bis(oxazoline)s was examined. Among them, unsymmetrical dithioacetals were found to be the best choice for attaining high enantioselectivity. The reaction of lithiated tert-butylthio(2-pyridylthio)methane with aldehydes proceeded with good diastereoselectivity as well as with good enantioselectivity. The enantioselective reaction was shown to proceed through dynamic thermodynamic resolution. Mercury(II) chloride effected hydrolysis of the dithioacetal moiety of the products to 2-hydroxyaldehydes, which were directly reduced to give the optically active 1,2diols. [ABSTRACT FROM AUTHOR]

The reaction of the α-carbanion of p-tolyl 2-(trimethylsilyl)ethyl sulfoxide with esters followed by reduction with DIBAL gave α-(trimethylsilyl)methyl-β-hydroxysulfoxides with high stereoselectivity. The stereoselective reaction was demonstrated to proceed through a dynamic kinetic resolution pathway via a six-membered cyclic transition state involving Si-O interaction. These reactions provide a convenient route for the synthesis of optically pure allylic alcohols. [ABSTRACT FROM AUTHOR]