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Your search keyword '"Mosley, Ralph T."' showing total 2 results
Start Over Author "Mosley, Ralph T." Journal journal of organic chemistry
2 results on '"Mosley, Ralph T."'

1. Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities

Author

Singh, Sheo B., Zink, Deborah L., Liesch, Jerrold M., Mosley, Ralph T., Dombrowski, Anne W., Bills, Gerald F., Darkin-Rattray, Sandra J., Schmatz, Dennis M., and Goetz, Michael A.

Subjects
Chemistry, Organic -- Research, Peptides -- Physiological aspects, Epoxy compounds -- Physiological aspects, Histones -- Physiological aspects, Protozoa -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the apicidins, cyclic tetrapeptides which inhibit deacetylase and antiprotozoal agents. The isolation and elucidation of these apicidins from the Fusarium species, temperature-dependent NMR studies of the apicidins, molecular and NMR based conformation of their macrocyclic ring and apicidin's selected chemical modification are discussed.

Published
2002

2. Assignment of the liposidomycin diazepanone stereochemistry

Author

Knapp, Spencer, Morriello, Gregori J., Nandan, Santosh R., Emge, Thomas J., Doss, George A., Mosley, Ralph T., and Chen, Lijian

Subjects
Chemistry, Organic -- Research, Stereochemistry -- Research, Nucleosides -- Physiological aspects, Antibiotics -- Physiological aspects, Peptidoglycans -- Analysis, Amines -- Physiological aspects, Nuclear magnetic resonance spectroscopy -- Usage, X-ray crystallography -- Usage, Molecules -- Models, Biological sciences, Chemistry
Abstract

Research has been conducted on the liposidomycins, nucleoside antibiotics inhibiting bacterial peptidoglycan synthesis. The preparation of the model liposidomycin diazepanone via the intramolecular reductive amination reaction has been performed and the use of the NMR spectroscopy, X-ray crystallography and molecular modeling has been described.

Published
2001

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